Abstract
Influenza virus-specific cytotoxic T lymphocyte (CTLs) can be obtained from mice and humans infected with influenza A viruses1,2 and appear to be beneficial in the host response3. The viral target structure recognized by influenza virus-specific CTLs remains a controversial question for two reasons: first, previous specificity analyses were difficult to interpret because of heterogeneous CTL populations, and second, more than one viral protein has been detected serologically on the surface of influenza-infected cells4–10. To avoid these problems, anti-influenza A/PR/8/34 CTL clones were generated and tested for cytolytic activity on target cells infected with recombinant viruses containing known rearrangements of the genes of strains A/PR/8/34 and A/HK/1/68. We report here that one such CTL line lysed target cells only if the infecting virus possessed the polymerase gene P3 of A/PR/8/34. This suggests that the P3 gene product either induces a virus-specific cell-surface antigenic modification or is expressed on the surface of the infected cell, and hence is involved in recognition of target cells by the anti-influenza CTL line.
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Bennink, J., Yewdell, J. & Gerhard, W. A viral polymerase involved in recognition of influenza virus-infected cells by a cytotoxic T-cell clone. Nature 296, 75–76 (1982). https://doi.org/10.1038/296075a0
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DOI: https://doi.org/10.1038/296075a0
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