Abstract
It is generally accepted from the darwinian theory of evolution that a progressive increase in population adaptation will occur in populations containing genetic variation in fitness, until a stable equilibrium is reached and/or the additive genetic variation is exhausted. However, the theoretical literature of population genetics documents exceptions where mean population fitness may decrease in response to evolutionary changes in gene frequency, due to varying selective coefficients1–4, sexual selection5,6or to epistatic interactions between loci7. Until now, no examples of such exceptions have been documented from fitness estimates in either natural or experimental populations. We present here direct evidence that, as a result of epistatic interactions between adaptive mutations, mean population fitness can decrease in asexual evolving populations of the yeast Saccharomyces cerevisiae.
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References
Lewontin, R. C. Genetics 43, 419–434 (1958).
Li, C. C. Biometrics 23, 397–484 (1967).
Sacks, J. M. Genetics 56, 705–708 (1967).
MacArthur, R. H. Proc. natn. Acad. Sci. U.S.A. 48, 1893–1897 (1962).
Darwin, C. The Descent of Man and Selection in Relation to Sex 2nd edn (Murray, London, 1874).
Lande, R. Evolution 34, 292–305 (1980).
Moran, P. A. P. Ann. hum. Genet. 27, 383–393 (1964).
Paquin, C. & Adams, J. Nature 302, 495–500 (1983).
Harper, J. L. Population Biology of Plants (Academic, London, 1977).
Kubitschek, H. E. Introduction to Research with Continuous Cultures (Prentice-Hall, New Jersey, 1980).
Cavalli, L. L. & Maccacaro, G. A. Heredity 6, 311–331 (1952).
Malmberg, R. L. Genetics 56, 607–621 (1977).
Hedrick, P., Jain, S. K. & Holden, L. Evol. Biol. 11, 101–184 (1978).
Allard, R. W. Principles of Plant Breeding (Wiley, New York, 1960).
Falconer, D. S. Introduction to Quantitative Genetics 2nd edn (Longman, London, 1981).
Crow, J. F. & Kimura, M. Am. Nat. 99, 439–450 (1965).
Charlesworth, B. Nature 302, 479–480 (1983).
Novick, A. in Perspectives in Marine Biology (ed. Buzzati-Traverso, A. A.) 533–547 (University of California Press, 1960).
Isaacs, J. in Perspectives in Marine Biology (ed. Buzzati-Traverso, A. A.) 545 (University of California Press, 1960).
Holland, J. et al. Science 215, 1577–1585 (1982).
Wright, S. Genetics 16, 97–159 (1931).
Paquin, C. & Adams, J. Curr. Genet. 6, 21–24 (1982).
Helling, R. B., Kinney, T. & Adams, J. J. gen. Microbiol. 123, 129–141 (1981).
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Paquin, C., Adams, J. Relative fitness can decrease in evolving asexual populations of S. cerevisiae. Nature 306, 368–371 (1983). https://doi.org/10.1038/306368a0
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DOI: https://doi.org/10.1038/306368a0
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