Abstract
Pre-B lymphocytes, and hybridomas derived from them, synthesize immunoglobulin heavy (IgH) chain in the absence of light (L) chain1. In the Abelson virus transformed line 18-81, which is representative of the pre-B cell stage, we observed that at least some of the H-chains are bound to a protein other than L-chain. Here we show that the protein (which we term immunoglobulin heavy-chain binding protein, BiP) binds non-covalently to free IgH, but not to IgH associated with IgL.
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References
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Haas, I., Wabl, M. Immunoglobulin heavy chain binding protein. Nature 306, 387–389 (1983). https://doi.org/10.1038/306387a0
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DOI: https://doi.org/10.1038/306387a0
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