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The murine T-cell receptor uses a limited repertoire of expressed Vβ gene segments

Nature volume 316, pages 517–523 (1985)Cite this article

Abstract

Only 10 different Vβ gene segments were found when the sequences of 15 variable (Vβ) genes of the mouse T-cell receptor were examined. From this analysis we calculate that the total number of expressed Vβ gene segments may be 21 or fewer, which makes the expressed germline Vβ repertoire much smaller than that of the immunoglobulin heavy-chain or light-chain genes. We suggest that βchain somatic diversification is concentrated at the Vβ−Dβ−Jβ junctions.

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Authors and Affiliations

  1. Division of Biology, California Institute of Technology, Pasadena, California, 91125, USA

    Richard K. Barth, Byung S. Kim, Nancy C. Lan, Tim Hunkapiller, Nancy Sobieck, Astar Winoto & Leroy Hood

  2. Department of Pathology, Stanford Medical School, Palo Alto, California, 94304, USA

    Howard Gershenfeld, Craig Okada & Irving L. Weissman

  3. Department of Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, 19111, USA

    Dan Hansburg

  4. Department of Microbiology/Immunology, Northwestern University, Chicago, Illinois, 60611, USA

    Byung S. Kim

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  1. Richard K. Barth
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Barth, R., Kim, B., Lan, N. et al. The murine T-cell receptor uses a limited repertoire of expressed Vβ gene segments. Nature 316, 517–523 (1985). https://doi.org/10.1038/316517a0

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