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Allosteric effects of DNA on transcriptional regulators

Nature volume 392, pages 885–888 (1998)Cite this article

Abstract

Selective gene transcription is mediated in part by regulatory proteins that bind to DNA response elements. These regulatory proteins receive global information from signal-transduction events. But transcriptional regulators may also be modified in an allosteric manner by response elements themselves to generate the pattern of regulation that is appropriate to an individual gene.

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Figure 1: Different effects of DNA response elements on regulator function.
Figure 2: A simple model for control of glucocorticoid-receptor (GR) function by DNA sequence.

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Acknowledgements

We thank W. Herr, C. Jamieson, A. Johnson, E. Levine, D. B. Starr and J. Weissman for comments on the manuscript. The authors are supported by grants from the NIH and the NSF.

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  1. the Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, 94143-0450 , California, USA

    Jeffrey A. Lefstin & Keith R. Yamamoto

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Lefstin, J., Yamamoto, K. Allosteric effects of DNA on transcriptional regulators. Nature 392, 885–888 (1998). https://doi.org/10.1038/31860

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