Abstract
Friend murine leukaemia virus complex (FV) causes an immunosuppressive retrovirus-induced disease. In certain mouse strains, FV shows striking similarities to human immunodeficiency virus (HIV) infection in man in that infected mice have severe T-cell immunosuppression but also develop virus-neutralizing antibodies incapable of eliminating infected cells. Previously we noted the influence of mouse major histocompatibility complex (H–2) genes on both FV-induced immunosuppression1 and on ability to protect mice against FV by immunizing with a vaccinia–Friend murine leukaemia helper virus (F-MuLV) envelope (env) recombinant virus2. Here we show that different subregions of H–2 are involved in susceptibility to virus-induced immunosuppression (H–2D subregion) and protective immunization with a recombinant vaccinia virus (H–2K or I–A subregions). Thus, susceptibility to virus-induced immunosuppression does not preclude protection by vaccinia–Friend immunization. The mechanism of protection seems to involve priming of immune T cells, and not initial induction of neutralizing antibodies or cytotoxic T lymphocytes (CTL) (ref. 2). Subsequent virus challenge generates a secondary response, resulting in appearance of IgG antibodies and CTL. In human HIV infection there could also be host genetic influences on elements of disease pathogenesis, such as immunosuppression, and on the success of T-cell priming by potential protective vaccines.
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References
Morrison, R. P., Nishio, J. & Chesebro, B. J. exp. Med. 163, 301–314 (1986).
Earl, P. L. et al. Science 234, 728–731 (1986).
Teich, N., Wyke, J., Mak, T., Bernstein, A. & Hardy, W. in RNA Tumor Viruses, Molecular Biology of Tumor Viruses (eds Weiss, R., Teich, N., Varmus, H. & Coffin, J.) 785–998 (Cold Spring Harbor Laboratory, New York, 1984).
Chesebro, B. & Wehrly, K. J. exp. Med. 143, 73–84 (1976).
Chesebro, B., Bloom, M., Wehrly, K. & Nishio, J. J. Virol. 32, 832–837 (1979).
Doig, D. & Chesebro, B. J. exp. Med. 150, 10–19 (1979).
Chesebro, B. & Wehrly, K. Proc. natn. Acad. Sci. U.S.A. 76, 425–429 (1979).
Doig, D. & Chesebro, B. J. exp. Med. 148, 1109–1121 (1978).
Chesebro, B., Wehrly, K., Doig, D. & Nishio, J. Proc. natn. Acad. Sci. U.S.A. 76, 5784–5788 (1979).
Weiss, R. A. et al. Nature 316, 69–72 (1985).
Robert-Guroff, M., Brown, M. & Gallo, R. C. Nature 316, 72–74 (1985).
McDougal, J. S. et al. J. Immunol. Meth. 76, 171–183 (1985).
Essex, M. et al. Science 220, 859–862 (1983).
Lane, H. C. & Fauci, A. S. A. Rev. Immun. 3, 477–500 (1985).
Rook, A. H. et al. J. Immun. 138, 1064–1067 (1987).
Cremer, K. J., Mackett, M., Wohlenberg, C., Notkins, A. L. & Moss, B. Science 228, 737–740 (1985).
Green, I., Paul, W. E. & Benacerraf, B. J. J. exp. Med. 123, 859–879 (1966).
McDevitt, H. O. J. Immun. 100, 485–492 (1968).
Chesebro, B., Wehrly, K. & Stimpfling, J. J. exp. Med. 140, 1457–1467 (1974).
Britt, W. J. & Chesebro, B. J. exp. Med. 157, 1736–1745 (1983).
Smith, G. L., Murphy, B. R. & Moss, B. Proc. natn. Acad. Sci. U.S.A. 80, 7155–7159 (1983).
Chesebro, B., Britt, W., Evans, L., Wehrly, K., Nishio, J. & Cloyd, M. Virology 127, 134–148 (1983).
Wolfe, J. H., Blank, K. J. & Pincus, T. Immunogenetics 12, 187–190 (1981).
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Morrison, R., Earl, P., Nishio, J. et al. Different H–2 subregions influence immunization against retrovirus and immunosuppression. Nature 329, 729–732 (1987). https://doi.org/10.1038/329729a0
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DOI: https://doi.org/10.1038/329729a0
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