Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Two-tiered regulation of spatially patterned engrailed gene expression during Drosophila embryogenesis

Nature volume 332, pages 604–609 (1988)Cite this article

Abstract

A regulatory cascade, initiated during the syncytial stage of embryogenesis, culminates in the striped pattern of engrailed gene expression at the cellular blastoderm stage. The early regulatory genes, for example the pair-rule genes, are expressed transiently and as their products decay a distinct regulatory programme involving segment polarity genes takes over. This late programme maintains and perhaps modifies the striped pattern of engrailed expression through interactions that may involve cell communication.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Kornberg, T. et al. Cell 40, 45–53 (1985).

    Article  CAS  Google Scholar 

  2. Fjose, A., McGinnis, W. J. & Gehring, W. J. Nature 313, 284–289 (1985).

    Article  ADS  CAS  Google Scholar 

  3. Baker, N. EMBO J. 6, 1765–1773 (1987).

    Article  CAS  Google Scholar 

  4. Nüsslein-Volhard, C. & Wieschaus, E. Nature 287, 795–801 (1980).

    Article  ADS  Google Scholar 

  5. Kornberg, T. Proc. natn. Acad. Sci. U.S.A. 78, 1095–1099 (1981).

    Article  ADS  CAS  Google Scholar 

  6. Nüsslein-Volhard, C., Frohnhöfer, H. G. & Lehmann, R. Science 238, 1675–1681 (1987).

    Article  ADS  Google Scholar 

  7. Gaul, U. & Jäckle, H. Cell 51, 549–555 (1987).

    Article  CAS  Google Scholar 

  8. Carroll, S. B. & Scott, M. P. Cell 45, 113–126 (1986).

    Article  CAS  Google Scholar 

  9. Scott, M. P. & O'Farrell, P. H. A. Rev. Cell Biol. 2, 49–80 (1986).

    Article  CAS  Google Scholar 

  10. DiNardo, S. et al. Cell 43, 59–69 (1985).

    Article  CAS  Google Scholar 

  11. Howard, K. & Ingham, P. Cell 44, 949–957 (1986).

    Article  CAS  Google Scholar 

  12. DiNardo, S. & O'Farrell, P. H. Genes & Dev. 1, 1212–1225 (1987).

    Article  CAS  Google Scholar 

  13. Hafen, E., Kuroiwa, A. & Gehring, W. J. Cell 37, 833–841 (1984).

    Article  CAS  Google Scholar 

  14. Macdonald, P. M., Ingham, P. & Struhl, G. Cell 47, 721–734 (1986).

    Article  CAS  Google Scholar 

  15. Harding, K. et al. Science 233, 953–959 (1986).

    Article  ADS  CAS  Google Scholar 

  16. Kilcherr, F., Baumgartner, S., Bopp, D., Frei, E. & Noll, M. Nature 321, 493–499 (1986).

    Article  ADS  Google Scholar 

  17. Morata, G. & Lawrence, P. A. Devl. Biol. 56, 227–240 (1977).

    Article  CAS  Google Scholar 

  18. Spradling, A. C. & Rubin, G. M. Science 218, 341–347 (1982).

    Article  ADS  CAS  Google Scholar 

  19. Drees, B. et al. EMBO J. 6, 2803–2809 (1987).

    Article  CAS  Google Scholar 

  20. Poole, S. J. et al. Cell 40, 37–43 (1985).

    Article  CAS  Google Scholar 

  21. Hiromi, Y., Kuroiwa, A. & Gehring, W. J. Cell 43, 603–613 (1985).

    Article  CAS  Google Scholar 

  22. Weir, M. & Kornberg, T. Nature 318, 433–439 (1985).

    Article  ADS  CAS  Google Scholar 

  23. Campos-Ortega, J. A. & Hartenstein, V. The Embryonic Development of Drosophila melanogaster (Springer, Berlin, 1985).

    Book  Google Scholar 

  24. Carroll, S. B. & Scott, M. P. Cell 43, 47–57 (1985).

    Article  CAS  Google Scholar 

  25. Frasch, M. et al. EMBO J. 6, 749–759 (1987).

    Article  CAS  Google Scholar 

  26. Martinez-Arias, A. J. Embryol. exp. Morph. 87, 99–114 (1985).

    CAS  PubMed  Google Scholar 

  27. Perrimon, N. & Mahowald, A. P. Devl. Biol. 119, 587–600 (1987).

    Article  CAS  Google Scholar 

  28. Gergen, J. P., Coulter, D. & Wieschaus, E. in Gametogenesis and the Early Embryo (ed. J. Gall 195–220 (New York, 1986).

    Google Scholar 

  29. Frasch, M. & Levine, M. Genes & Dev. 1, 981–995 (1987).

    Article  CAS  Google Scholar 

  30. Struhl, G. Nature 318, 677–680 (1985).

    Article  ADS  CAS  Google Scholar 

  31. Ingham, P. W., Howard, K. R. & Ish-Horowicz, D. Nature 318, 439–445 (1985).

    Article  ADS  CAS  Google Scholar 

  32. Rijsewijk, F. et al. Cell 50, 649–657 (1987).

    Article  CAS  Google Scholar 

  33. Wieschaus, E. & Riggleman, R. Cell 49, 177–184 (1987).

    Article  CAS  Google Scholar 

  34. Joyner, A. L. & Martin, G. R. Genes & Dev. 1, 29–38 (1987).

    Article  CAS  Google Scholar 

  35. Martinez-Arias, A., Baker, N. & Ingham, P. W. Development (submitted).

  36. Lawrence, P. A., Johnston, P., Macdonald, P. & Struhl, G. Nature 328, 440–442 (1987).

    Article  ADS  CAS  Google Scholar 

  37. Carroll, S. B. et al. Genes & Dev. 2 (in the press).

  38. French, V., Bryant, P. J. & Bryant, S. Science 193, 969–981 (1976).

    Article  ADS  CAS  Google Scholar 

  39. Wright, D. A. & Lawrence, P. A. Devl. Biol. 85, 317–327 (1981).

    Article  CAS  Google Scholar 

  40. Kuner, J. M. et al. Cell 42, 309–316 (1985).

    Article  CAS  Google Scholar 

  41. Hiromi, Y. & Gehring, W. Cell 50, 963–974 (1987).

    Article  CAS  Google Scholar 

  42. Van der Meer, S. Drosoph. Inf. Sen. 52, 160 (1977).

    Google Scholar 

  43. Ingham, P. W., Baker, N. & Martinez-Arias, A. Nature 331, 73–75 (1988).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Author notes

  1. Stephen DiNardo

    Present address: The Rockefeller University, 1230 York Ave., New York, New York, 10021, USA

  2. Judith A. Kassis

    Present address: Department of Health and Human Services, PHS PDA, Bethesda, Maryland, 20892, USA

Authors and Affiliations

  1. Department of Biochemistry and Biophysics, UCSF School of Medicine, San Francisco, California, 94143-0448, USA

    Stephen DiNardo, Elizabeth Sher, Jill Heemskerk-Jongens, Judith A. Kassis & Patrick H. O'Farrell

Authors
  1. Stephen DiNardo
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Elizabeth Sher
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jill Heemskerk-Jongens
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Judith A. Kassis
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Patrick H. O'Farrell
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

DiNardo, S., Sher, E., Heemskerk-Jongens, J. et al. Two-tiered regulation of spatially patterned engrailed gene expression during Drosophila embryogenesis. Nature 332, 604–609 (1988). https://doi.org/10.1038/332604a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/332604a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing