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Inositol phosphates and cell signalling

Nature volume 341, pages 197–205 (1989)Cite this article

Abstract

Inositol 1,4,5-trisphosphate is a second messenger which regulates intracellular calcium both by mobilizing calcium from internal stores and, perhaps indirectly, by stimulating calcium entry. In these actions it may function with its phosphorylated metabolite, inositol 1,3,4,5-tetrakisphosphate. The subtlety of calcium regulation by inositol phosphates is emphasized by recent studies that have revealed oscillations in calcium concentration which are perhaps part of a frequency-encoded second-messenger system.

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References

  1. Berridge, M. J. & Irvine, R. F. Nature 312, 315–321 (1984).

    ADS  CAS  PubMed  Google Scholar 

  2. Nishizuka, Y. Nature 334, 661–665 (1988).

    ADS  CAS  PubMed  Google Scholar 

  3. Berridge, M. J. A. Rev. Biochem. 56, 159–193 (1987).

    CAS  Google Scholar 

  4. Hokin, L. E. A. Rev. Biochem. 54, 205–235 (1985).

    CAS  Google Scholar 

  5. Abdel-Latif, A. A. Pharmac. Rev. 38, 227–272 (1986).

    CAS  Google Scholar 

  6. Michell, R. H., Drummond, A. H. & Downes, C. P. (eds) Inositol Lipids in Cell Signalling (Academic, London, 1989).

  7. Berridge, M. J. & Michell, R. H. Phil. Trans. R. Soc. B. 320, 235–436 (1988).

    Google Scholar 

  8. Parthasarathy, R. & Eisenberg, F. Biochem. J. 235, 313–322 (1986).

    CAS  PubMed  PubMed Central  Google Scholar 

  9. Agranoff, B. W. Life Sci. 32, 2047–2054 (1983).

    CAS  PubMed  Google Scholar 

  10. Shears, S. B. Biochem. J. 260, 313–324 (1989).

    CAS  PubMed  PubMed Central  Google Scholar 

  11. Irvine, R. F., Moor, R. M., Pollock, W. K., Smith, P. M. & Wreggett, K. A. Phil. Trans. R. Soc. B 320, 281–298 (1988).

    CAS  Google Scholar 

  12. Majerus, P. W. et al. J. biol. Chem. 263, 3051–3054 (1988).

    CAS  PubMed  Google Scholar 

  13. Streb, H., Bayerdorffer, E., Hasse, W., Irvine, R. F. & Schulz, I. J. Membrane Biol. 81, 241–253 (1984).

    CAS  Google Scholar 

  14. Thévenod, F. et al. J. Membrane Biol. 109, 173–186 (1989).

    Google Scholar 

  15. Supattapone, S., Worley, P. F., Baraban, J. M. & Snyder, S. H. J. biol. Chem. 263, 1530–1534 (1988).

    CAS  PubMed  Google Scholar 

  16. Ross, C. A. et al. Nature 339, 468–470 (1989).

    ADS  CAS  PubMed  Google Scholar 

  17. Volpe, P. et al. Proc. natn. Acad. Sci. U.S.A. 85, 1091–1095 (1987).

    ADS  Google Scholar 

  18. Chueh, S.-H. & Gill, D. L. J. biol. Chem. 261, 13883–13886 (1986).

    CAS  PubMed  Google Scholar 

  19. Bourne, H. Cell 53, 669–671 (1988).

    CAS  PubMed  Google Scholar 

  20. Ghosh, T. K., Mullaney, J. M., Tarazi, F. I. & Gill, D. L. Nature 340, 236–239 (1989).

    ADS  CAS  PubMed  Google Scholar 

  21. Strupish, J., Cooke, A. M., Potter, B. V. L. Gigg, R. & Nahorski, S. R. Biochem. J. 253, 901–905 (1988).

    CAS  PubMed  PubMed Central  Google Scholar 

  22. Taylor, C. W., Berridge, M. J., Brown, K., Cooke, A. M. & Potter, B. V. L. Biochem. biophys. Res. Commun. 150, 626–632 (1988).

    CAS  PubMed  Google Scholar 

  23. Stauderman, K. A., Harris, G. D. & Lovenberg, W. Biochem. J. 255, 677–683 (1988).

    CAS  PubMed  PubMed Central  Google Scholar 

  24. Hill, T. D., Berggren, P.-O. & Boynton, A. L. Biochem. biophys. Res. Commun. 149, 897–901 (1987).

    CAS  PubMed  Google Scholar 

  25. Ehrlich, B. E. & Watras, J. Nature 336, 583–586 (1988).

    ADS  CAS  PubMed  Google Scholar 

  26. Meyer, T., Holowka, D. & Stryer, L. Science 240, 653–656 (1988).

    ADS  CAS  PubMed  Google Scholar 

  27. Walker, J. N., Somlyo, A. V., Goldman, Y. E., Somlyo, A. P. & Trentham, D. R. Nature 327, 249–251 (1987).

    ADS  CAS  PubMed  Google Scholar 

  28. Parker, I. J. Physiol., Lond. 407, 95P (1988).

    ADS  Google Scholar 

  29. Berridge, M. J., Cobbold, P. H. & Cuthbertson, K. S. R. Phil. Trans. R. Soc. B. 320, 325–343 (1988).

    CAS  Google Scholar 

  30. Seiler, S. M., Arnold, A. J. & Stanton, H. C. Biochem. Pharmac. 36, 3331–3337 (1987).

    CAS  Google Scholar 

  31. Shah, J. & Pant, H. C. Biochem. J. 250, 617–620 (1988).

    CAS  PubMed  PubMed Central  Google Scholar 

  32. Joseph, S. K. & Williamson, J. R. J. biol. Chem. 261, 14658–14664 (1986).

    CAS  PubMed  Google Scholar 

  33. Joseph, S. K., Rice, H. L. & Williamson, J. R. Biochem. J. 258, 261–265 (1989).

    CAS  PubMed  PubMed Central  Google Scholar 

  34. Danoff, S. K., Suppattapone, S. & Snyder, S. H. Biochem. J. 254, 701–705 (1988).

    CAS  PubMed  PubMed Central  Google Scholar 

  35. Supattapone, S. et al. Proc. natn. Acad. Sci. U.S.A. 85, 8747–8750 (1988).

    ADS  CAS  Google Scholar 

  36. Willcocks, A. L., Potter, B. V. L., Cooke, A. M. & Nahorski, S. R. Eur. J. Pharm. 155, 181–183 (1988).

    CAS  Google Scholar 

  37. Taylor, C. W., Berridge, M. J., Cooke, A. M. & Potter, B. V. L. Biochem. J. 259, 645–650 (1989).

    CAS  PubMed  PubMed Central  Google Scholar 

  38. Pozzan, T. & Meldolesi, J. Expl Cell Res. 171, 271–283 (1987).

    Google Scholar 

  39. Eberhard, D. A. & Holz, R. W. Trends Neurosci. 11, 517–520 (1988).

    CAS  PubMed  Google Scholar 

  40. Penner, R., Matthews, G. & Neher, E. Nature 334, 499–504 (1988).

    ADS  CAS  PubMed  Google Scholar 

  41. Kuno, N. & Gardner, P. Nature 326, 301–304 (1987).

    ADS  CAS  PubMed  Google Scholar 

  42. Putney, J. W. Cell Calcium 7, 1–12 (1986).

    CAS  PubMed  Google Scholar 

  43. Merritt, J. E. & Rink, T. J. J. biol. Chem. 262, 4958–4960 (1987).

    CAS  PubMed  Google Scholar 

  44. Hallam, T. J., Jacob, R. & Merritt, J. E. Biochem. J. 255, 179–184 (1988).

    CAS  PubMed  PubMed Central  Google Scholar 

  45. Irvine, R. F. in Inositol Lipids in Cell Signalling (eds Michell, R. H., Drummond, A. H. & Downes, C. P.) 135–161 (Academic, London, 1989).

    Google Scholar 

  46. Irvine, R. F. & Moor, R. M. Biochem. J. 240, 917–920 (1986).

    CAS  PubMed  PubMed Central  Google Scholar 

  47. Changya, L., Gallacher, D. V., Irvine, R. F., Potter, B. V. L. & Petersen, O. H. J. Membrane Biol. 109, 85–93 (1989).

    CAS  Google Scholar 

  48. Changya, L., Gallacher, D. V., Irvine, R. F. & Petersen, O. H. FEBS Lett. 251, 43–48 (1989).

    CAS  PubMed  Google Scholar 

  49. Hill, T. D., Dean, N. M. & Boynton, A. L. Science 242, 1176–1178 (1988).

    ADS  CAS  PubMed  Google Scholar 

  50. Tsien, R. Y. & Poenie, M. Trends biochem. Sci. 11, 450–455 (1986).

    CAS  Google Scholar 

  51. O'Sullivan, A. J., Cheek, T. R., Moreton, R. B., Berridge, M. J. & Burgoyne, R. D. EMBO J. 8, 401–411 (1989).

    CAS  PubMed  PubMed Central  Google Scholar 

  52. Miyazaki, S. et al. Devl Biol. 118, 259–267 (1986).

    CAS  Google Scholar 

  53. Connor, J. A., Cornwall, M. C. & Williams, G. H. J. biol. Chem. 262, 2919–2927 (1987).

    CAS  PubMed  Google Scholar 

  54. Payne, R. & Fein, A. J. Cell Biol. 104, 933–937 (1987).

    CAS  Google Scholar 

  55. Benjamin, C. W., Connor, J. A., Tarpley, W. G. & Gorman, R. R. Proc. natn. Acad. Sci. U.S.A. 85, 4345–4349 (1988).

    ADS  CAS  Google Scholar 

  56. Berridge, M. J. J. Physiol., Lond 403, 589–599 (1988).

    CAS  PubMed  PubMed Central  Google Scholar 

  57. Busa, W. B., Ferguson, J. E., Joseph, S. K., Williamson, J. R. & Nuccitelli, R. J. Cell Biol. 101, 677–682 (1985).

    CAS  PubMed  Google Scholar 

  58. Mulder, B. J. M., de Tombe, P. P. & ter Keurs, H. E. D. J. J. gen. Physiol. 93, 943–961 (1989).

    CAS  PubMed  Google Scholar 

  59. Lakatta, E. G., Capogrossi, M. C., Spurgeon, H. A. & Stern, M. D. in Cell Calcium Metabolism (ed. Fiskum, G.) 529–543 (Plenum, New York, 1989).

    Google Scholar 

  60. Kort, A. A., Capogrossi, M. C. & Lakatta, E. G. Circulation Res. 57, 844–855 (1985).

    CAS  PubMed  Google Scholar 

  61. Leong, D. A. et al. J. Cell Biol. 107, 498a (1988).

    Google Scholar 

  62. Jacob, R. Cell Calcium (in the press).

  63. Saez, J. C., Connor, J. A., Spray, D. C. & Bennett, M. V. L. Proc. natn. Acad Sci. U.S.A. 86, 2708–2712 (1989).

    ADS  CAS  Google Scholar 

  64. Gardiner, D. M. & Grey, R. D. J. Cell Biol. 96, 1159–1163 (1983).

    CAS  PubMed  PubMed Central  Google Scholar 

  65. Swann, K. & Whitaker, M. J. Cell Biol. 103, 2333–2342 (1986).

    CAS  Google Scholar 

  66. Gilkey, J. C., Jaffe, L. F., Ridgeway, E. B. & Reynolds, G. T. J. Cell Biol. 76, 448–466 (1978).

    CAS  PubMed  PubMed Central  Google Scholar 

  67. Berridge, M. J. & Galione, A. FASEB J. 2, 3074–3082 (1988).

    CAS  PubMed  Google Scholar 

  68. Rapp, P. E. & Berridge, M. J. J. exp. Biol. 93, 119–132 (1981).

    CAS  Google Scholar 

  69. Woods, N. M., Cuthbertson, K. S. R. & Cobbold, P. H. Nature 319, 600–602 (1986).

    ADS  CAS  PubMed  Google Scholar 

  70. Jacob, R., Merritt, J. E., Hallam, T. J. & Rink, T. J. Nature 335, 40–45 (1988).

    ADS  CAS  PubMed  Google Scholar 

  71. Prentki, M. et al. J. biol. Chem. 263, 11044–11047 (1988).

    CAS  PubMed  Google Scholar 

  72. Gray, P. T. A. J. Physiol., Lond. 406, 35–53 (1989).

    Google Scholar 

  73. Yule, D. I. & Gallacher, D. V. FEBS Lett. 239, 358–362 (1988).

    CAS  PubMed  Google Scholar 

  74. Woods, N. M., Cuthbertson, K. S. R. & Cobbold, P. H. Cell Calcium 8, 79–100 (1987).

    CAS  PubMed  Google Scholar 

  75. Meyer, T. & Stryer, L. Proc. natn. Acad. Sci. U.S.A 85, 5051–5055 (1988).

    ADS  CAS  Google Scholar 

  76. Biden, T. J. & Wollheim, C. B. J. biol. Chem. 261, 11931–11934 (1986).

    CAS  PubMed  Google Scholar 

  77. Wakui, M., Potter, B. V. L. & Petersen, O. H. Nature 339, 317–320 (1989).

    ADS  CAS  PubMed  Google Scholar 

  78. Payne, R., Walz, B., Levy, S. & Fein, A. Phil. Trans. R. Soc. B. 320, 359–379 (1988).

    CAS  Google Scholar 

  79. Rooney, T. A., Sass, E. J. & Thomas, A. P. J. biol. Chem. 264 (in the press).

  80. Kuba, K. J. Physiol., Lond. 298, 251–269 (1980).

    CAS  PubMed  PubMed Central  Google Scholar 

  81. Miyazaki, S. J. Cell Biol. 106, 345–353 (1988).

    CAS  PubMed  Google Scholar 

  82. Ohya, Y. et al. Pflügers Arch. 412, 382–389 (1988).

    CAS  PubMed  Google Scholar 

  83. Wilson, H. A., Greenblatt, D., Poenie, M., Finkelman, F. D. & Tsien, R. Y. J. exp. Med. 166, 601–606 (1987).

    CAS  PubMed  Google Scholar 

  84. Tombes, R. M. & Borisy, G. G. J. Cell Biol. 109, 627–636 (1989).

    CAS  PubMed  Google Scholar 

  85. Sanderson, M. J., Chow, I. & Dirksen, E. R. Am. J. Physiol. 254, C63–C74 (1988).

    CAS  PubMed  Google Scholar 

  86. Lawrence, T. S., Beers, W. H. & Gilula, N. B. Nature 272, 501–506 (1978).

    ADS  CAS  PubMed  Google Scholar 

  87. Sage, S. O., Adams, D. J. & van Breemen, C. J. biol. Chem. 264, 6–9 (1989).

    CAS  PubMed  Google Scholar 

  88. Graf, E., Empson, K. L. & Eaton, J. W. J. biol. Chem. 262, 11647–11650 (1987).

    CAS  PubMed  Google Scholar 

  89. Wilson, D. B. et al. J. biol. Chem. 260, 13496–13501 (1985).

    CAS  PubMed  Google Scholar 

  90. Sekar, M. C., Dixon, J. E. & Hokin, L. E. J. biol. Chem. 262, 340–344 (1987).

    CAS  PubMed  Google Scholar 

  91. Wong, N. S., Barker, C. J., Shears, S. B., Kirk, C. J. & Michell, R. H. Biochem. J. 252, 1–5 (1988).

    CAS  PubMed  PubMed Central  Google Scholar 

  92. Willcocks, A. L., Strupish, J., Irvine, R. F. & Nahorski, S. R. Biochem. J. 257, 297–300 (1989).

    CAS  PubMed  PubMed Central  Google Scholar 

  93. Johnson, R. M., Wasilenko, W. J., Mattingly, R. R., Webor, M. J. & Garrison, J. C. Science (in the press).

  94. Stephens, L. R. et al. Biochem. J. 249, 283–292 (1988).

    CAS  PubMed  PubMed Central  Google Scholar 

  95. Johnson, L. F. & Tate, M. E. Canadian J. Chem. 47, 63–73 (1969).

    CAS  Google Scholar 

  96. Stephens, L. R., Hawkins, P. T., Barker, C. J. & Downes, C. P. Biochem. J. 253, 721–733 (1988).

    CAS  PubMed  PubMed Central  Google Scholar 

  97. Barker, C. J., Morris, A. J., Kirk, C. J., & Michell, R. H. Biochem. Soc. Trans. 16, 984–985 (1988).

    CAS  Google Scholar 

  98. Tilly, B. C. et al. Biochem. J. 244, 129–135 (1987).

    CAS  PubMed  PubMed Central  Google Scholar 

  99. Martin, J-B., Foray, M-F., Klein, G. & Satre, M. Biochim. biophys. Acta 931, 16–25 (1987).

    CAS  PubMed  Google Scholar 

  100. Bradford, P. G. & Rubin, R. P. J. biol. Chem. 261, 15644–15647 (1986).

    CAS  PubMed  Google Scholar 

  101. French, P. J., Bunce, C. M., Brown, G., Creba, J. A. & Michell, R. H. Biochem. Soc. Trans. 16, 985–986 (1988).

    CAS  Google Scholar 

  102. Graf, E., Mahoney, J. R., Bryant, R. G. & Eaton, J. W. J. biol. Chem. 259, 3620–3624 (1987).

    Google Scholar 

  103. Vallejo, M., Jackson, T., Lightman, S. & Hanley, M. R. Nature 330, 656–658 (1987).

    ADS  CAS  PubMed  Google Scholar 

  104. Low, M. A. & Saltiel, A. R. Science 239, 268–275 (1988).

    ADS  CAS  PubMed  Google Scholar 

  105. Whitman, M. & Cantley, L. Biochim. biophys. Acta 948, 327–344 (1989).

    CAS  PubMed  Google Scholar 

  106. Coughlin, S. R., Escobedo, J. A. & Williams, L. J. Science 243, 1192–1194 (1989).

    ADS  Google Scholar 

  107. Traynor-Kaplan, A. E., Harris, A. L., Thompson, B. L., Taylor, P. & Sklar, L. A. Nature 334, 353–356 (1988).

    ADS  CAS  PubMed  Google Scholar 

  108. Auger, K. R., Serunian, L. A., Soltoff, S. P., Libby, P., & Cantley, L. C. Cell 57, 167–175 (1989).

    CAS  PubMed  Google Scholar 

  109. Lassing, I. & Lindberg, U. Expl Cell Res. 174, 1–15 (1988).

    CAS  Google Scholar 

  110. Janmey, P. A., Iida, K., Yin, H. L. & Stossel, R. P. J. biol. Chem. 262, 12228–12236 (1987).

    CAS  PubMed  Google Scholar 

  111. Hansen, C. A., Johanson, R. A., Williamson, M. T. & Williamson, J. R. J. biol. Chem. 262, 17319–17326 (1988).

    Google Scholar 

  112. Cubbitt, A. B. & Gershengorn, M. C. Biochem. J. 257, 639–644 (1989).

    Google Scholar 

  113. Cocco, L. et al. Biochem. biophys. Res. Commun. 154, 1266–1272 (1988).

    CAS  PubMed  Google Scholar 

  114. Sylvia, V., Curtin, G., Norman, J., Stec, J. & Busbee, D. Cell. 54, 651–658 (1988).

    CAS  PubMed  Google Scholar 

  115. Rhee, S. G., Suh, S-G., Ryu, S-H. & Lee, S. Y. Science 244, 546–550 (1989).

    ADS  CAS  PubMed  Google Scholar 

  116. Yoshioka, T., Inoue, H. & Hotta, Y. J. Biochem., Tokyo 97, 1251–1254 (1985).

    CAS  Google Scholar 

  117. Bloomquist, B. T. et al. Cell 54, 723–733 (1988).

    CAS  PubMed  Google Scholar 

  118. Berridge, M. J., Downes, C. P. & Hanley, M. R. Biochem. J. 206, 587–595 (1982).

    CAS  PubMed  PubMed Central  Google Scholar 

  119. Hallcher, L. M. & Sherman, W. R. J. biol. Chem. 255, 10896–10901 (1980).

    CAS  PubMed  Google Scholar 

  120. Batty, I. R. & Nahorski, S. R. Biochem. J. 247, 797–800 (1987).

    CAS  PubMed  PubMed Central  Google Scholar 

  121. Busa, W. B. Phil. Trans. R. Soc. B. 320, 415–426 (1988).

    CAS  Google Scholar 

  122. Randriamampita, C., Giaume, C. Neyton, J. & Trautmann, A. Pflügers Arch. 412, 462–468 (1988).

    CAS  PubMed  Google Scholar 

  123. Nagajski, D. J., Guthrie, S. C., Ford, C. C. & Warner, A. E. Development 105, 747–752 (1989).

    Google Scholar 

  124. Kao, K. R., Masin, Y. & Elinson, R. P. Nature 332, 371–373 (1986).

    ADS  Google Scholar 

  125. Busa, W. B. & Gimlich, R. D. Devl Biol 132, 315–324 (1989).

    CAS  Google Scholar 

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  1. Department of Zoology, AFRC Unit of Insect Neurophysiology and Pharmacology, Downing Street, Cambridge, CB2 3EJ, UK

    Michael J. Berridge

  2. AFRC Institute of Animal Physiology and Genetics Research, Cambridge Research Station, Babraham Hall, Cambridge, CB2 4AT, UK

    Robin F. Irvine

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Berridge, M., Irvine, R. Inositol phosphates and cell signalling. Nature 341, 197–205 (1989). https://doi.org/10.1038/341197a0

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