Abstract
The maternal gene bicoid (bed) determines pattern in the anterior half of the Drosophila embryo. It is reported here that the injection of bcd– mutant embryos with messenger RNAs that encode proteins consisting of heterologous acidic transcriptional activating sequences fused to the DNA-binding portion of the bcd gene product, can completely restore the anterior pattern of the embryo.
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References
Frohnhöfer, H. G. & Nüsslein-Volhard, C. Nature 324, 120–125 (1986).
Driever, W. & Nüsslein-Volhard, C. Cell 54, 83–93 (1988).
Frigerio, G., Burri, M., Bopp, D., Baumgartner, S. & Noll, M. Cell 47, 735–746 (1986).
Berleth, T. et al. EMBO J. 7, 1749–1756 (1988).
Driever, W. & Nusslein-Volhard, C. Cell 54, 95–104 (1988).
Tautz, D. Nature 332, 281–284 (1988).
Schröder, C. et al. EMBO J. 7, 2881–2888 (1988).
Lehmann, R. & Nüsslein-Volhard, C. Devl Biol. 119, 402–417 (1987).
Tautz, D. et al. Nature 327, 383–389 (1987).
Driever, W. & Nusslein-Volhard, C. Nature 337, 138–143 (1989).
Driever, W., Thoma, G. & Nüsslein-Volhard, C. Nature 340, 363–367 (1989).
McGinnis, W. et al. Nature 308, 428–433 (1984).
Laughon, A. & Scott, M. P. Nature 310, 25–31 (1984).
Gehring, W. J. Science 236, 1245–1252 (1987).
Desplan, C., Theis, J. & O'Farrell, P. Nature 318, 630–635 (1985).
Hoey, T. & Levine, M. Nature 332, 858–861 (1988).
Desplan, C., Theis, J. & O'Farrell, P. Cell 54, 1081–1090 (1988).
Hanes, S. & Brent, R. Cell 57, 1275–1283 (1989).
Jaynes, J. & O'Farrell, P. Nature 336, 744–749 (1988).
Fitzpatrick, D. & Ingles, J. Nature 337, 666–668 (1989).
Han, K., Levine, M. & Manley, J. Cell 56, 573–583 (1989).
Struhl, G., Struhl, K. & Macdonald, P. Cell 57, 1259–1273 (1989).
Brent, R. & Ptashne, M. Cell 43, 729–736 (1985).
Keegan, L., Gill, G. & Ptashne, M. Science 231, 699–704 (1986).
Ptashne, M. Nature 322, 697–701 (1986).
Struhl, K. Cell 49, 295–297 (1987).
Hope, I. & Struhl, K. Cell 46, 885–894 (1986).
Ma, J. & Ptashne, M. Cell 48, 847–853 (1987).
Ma, J. & Ptashne, M. Cell 51, 113–119 (1987).
Giniger, E. & Ptashne, M. Nature 330, 670–672 (1987).
Kakidani, H. & Ptashne, M. Cell 52, 161–167 (1988).
Webster, N., Jin, J. R., Green, S., Hollis, M. & Chambon, P. Cell 52, 169–178 (1988).
Fisher, J., Giniger, E., Ptashne, M. & Maniatis, T. Nature 332, 853–856 (1988).
Ma, J., Przibilla, E., Hu, J., Bogorad, L. & Ptashne, M. Nature 334, 631–633 (1988).
Courey, A. & Tjian, R. Cell 55, 887–898 (1988).
Tora, L. et al. Cell (in the press).
West, R., Yocum, R. & Ptashne, M. Molec. cell. Biol. 4, 2467–2478 (1984).
Ammerer, G. Meth. Enzymol. 101, 192–201 (1983).
Driever, W., Siegel, V. & Nüsslein-Volhard, C. Science (in the press).
Triezenberg, S., Kingsbury, R. & McKnight, S. Genes Dev. 2, 718–729 (1988).
Sadowski, I., Ma, J., Triezenberg, S. & Ptashne, M. Nature 335, 563–564 (1988).
Gill, G. & Ptashne, M. Nature 334, 721–724 (1988).
Ptashne, M. Nature 335, 683–689 (1988).
Mlodzik, M. & Gehring, W. Development 101, 421–435 (1987).
Gaul, U. & Jäckle, H. Cell 51, 549–555 (1987).
Gill, G. & Ptashne, M. Cell 51, 121–126 (1987).
Yocum, R., West, R. & Ptashne, M. Molec. cell. Biol. 4, 1985–1998 (1984).
Bunch, T. A., Grinblat, Y. & Goldstein, L. S. B. Nucleic Acids Res. 16, 1043–1061 (1988).
Rio, D. C. & Rubin, G. M. Molec. cell. Biol. 5, 1833–1838 (1985).
Melton, D. A. et al. Nucleic Acids Res. 12, 7035–7056 (1984).
Silver, P., Chiang, A. & Sadler, J. Genes Dev. 2, 707–717 (1988).
Jürgens, G. et al. Wilhelm Roux's Arc. dev. Biol. 196, 141–157 (1986).
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Driever, W., Ma, J., Nüsslein-Volhard, C. et al. Rescue of bicoid mutant Drosophila embryos by Bicoid fusion proteins containing heterologous activating sequences. Nature 342, 149–154 (1989). https://doi.org/10.1038/342149a0
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DOI: https://doi.org/10.1038/342149a0
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