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Universal control mechanism regulating onset of M-phase

Nature volume 344, pages 503–508 (1990)Cite this article

Abstract

The onset of M-phase is regulated by a mechanism common to all eukaryotic cells. Entry into M-phase is determined by activation of the p34cdc2 protein kinase which requires p34cdc2 dephosphorylation and association with cyclin.

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References

  1. Laskey, R., Fairman, M. & Blow, J. Science 246, 609–613 (1989).

    ADS  CAS  PubMed  Google Scholar 

  2. McIntosh, J. & Koonce, M. Science 246, 622–628 (1989).

    ADS  CAS  PubMed  Google Scholar 

  3. Fantes, P. & Nurse, P. in The Cell Cycle (ed. John, P.) 11–33 (Cambridge University Press, 1981).

    Google Scholar 

  4. Kirschner, M., Newport, J. & Gerhart, J. TIG 1, 41–47 (1985).

    Google Scholar 

  5. Mitchison, J. M. in The Biology of the Cell Cycle p. 313 (Cambridge University Press, Cambridge, 1971).

    Google Scholar 

  6. Hartwell, L. & Weinert, T. Science 246, 629–634 (1989).

    ADS  CAS  PubMed  Google Scholar 

  7. Fantes, P. & Nurse, P. Exptl. Cell Res. 107, 377–386 (1977).

    CAS  PubMed  Google Scholar 

  8. Nurse, P. Nature 256, 547–551 (1975).

    ADS  CAS  PubMed  Google Scholar 

  9. Nurse, P. & Thuriaux, P. Genetics 96, 627–637 (1980).

    CAS  PubMed  PubMed Central  Google Scholar 

  10. Lohka, M. J. J. Cell Sci. 92, 131–135 (1989).

    PubMed  Google Scholar 

  11. Fantes, P. Nature 279, 428–430 (1979).

    ADS  CAS  PubMed  Google Scholar 

  12. Russell, P. & Nurse, P. Cell 45, 145–153 (1986).

    CAS  PubMed  Google Scholar 

  13. Russell, P. & Nurse, P. Cell 49, 559–567 (1987).

    CAS  PubMed  Google Scholar 

  14. Russell, P. & Nurse, P. Cell 49, 569–576 (1987).

    CAS  PubMed  Google Scholar 

  15. Simanis, V. & Nurse, P. Cell 45, 261–268 (1986).

    CAS  PubMed  Google Scholar 

  16. Nurse, P. & Bissett, Y. Nature 292, 558–560 (1981).

    ADS  CAS  PubMed  Google Scholar 

  17. Beach, D., Durkacz, B. & Nurse, P. Nature 300, 706–709 (1982).

    ADS  CAS  PubMed  Google Scholar 

  18. Mendenhall, M. D., Jones, C. A. & Reed, S. I. Cell 50, 927–935 (1987).

    CAS  PubMed  Google Scholar 

  19. Pringle, J. R. & Hartwell, L. H. in The Molecular Biology of the Yeast Saccharomyces. Life Cycle and Inheritance (eds Strathern, J. N., Jones, E. W. & Broach, J. R.) 97–142 (Cold Spring Harbor Laboratory, New York, 1981).

    Google Scholar 

  20. Nurse, P., Thuriaux, P. & Nasmyth, P. Molec. gen. Genet. 146, 167–178 (1976).

    CAS  PubMed  Google Scholar 

  21. Carr, A. M., MacNeill, S. A., Hayles, J. & Nurse, P. Molec. gen. Genet. 218, 41–49 (1989).

    CAS  PubMed  Google Scholar 

  22. Booher, R. & Beach, D. H. Molec. cell. Biol. 6, 3523–3530 (1986).

    CAS  PubMed  PubMed Central  Google Scholar 

  23. MacNeill, S. A. & Nurse, P. Curr. Genet. 16, 1–6 (1989).

    CAS  PubMed  Google Scholar 

  24. Ogden, J. E. & Fantes, P. A. Curr. Genet. 10, 509–514 (1986).

    CAS  PubMed  Google Scholar 

  25. Young, P. & Fantes, P. J. Cell Sci. 88, 295–304 (1987).

    PubMed  Google Scholar 

  26. Moreno, S., Hayles, J. & Nurse, P. Cell 58, (1989).

    CAS  PubMed  Google Scholar 

  27. Booher, R. N., Alfa, C. E., Hyams, J. S. & Beach, D. H. Cell 58, 485–497 (1989).

    CAS  PubMed  Google Scholar 

  28. Brizuela, L., Draetta, G. & Beach, D. EMBO J. 6, 3507–3514 (1987).

    CAS  PubMed  PubMed Central  Google Scholar 

  29. Hindley, J., Phear, G., Stein, M. & Beach, D. Molec. cell. Biol. 7, 504–511 (1987).

    CAS  PubMed  PubMed Central  Google Scholar 

  30. Hayles, J., Beach, D., Durkacz, B. & Nurse, P. Molec. gen. Genet. 202, 291–293 (1986).

    CAS  PubMed  Google Scholar 

  31. Hayles, J., Aves, S. & Nurse, P. EMBO J. 5, 3373–3379 (1986).

    CAS  PubMed  PubMed Central  Google Scholar 

  32. Booher, R. & Beach, D. EMBO J. 6, 3441–3447 (1987).

    CAS  PubMed  PubMed Central  Google Scholar 

  33. Hagan, I., Hayles, J. & Nurse, P. J. Cell Sci. 91, 587–595 (1988).

    CAS  PubMed  Google Scholar 

  34. Masui, Y. & Markert, C. J. exp. Zool. 177, 129–146 (1971).

    CAS  PubMed  Google Scholar 

  35. Wasserman, W. & Smith, L. J. Cell Biol. 78, R15–R22 (1978).

    CAS  PubMed  PubMed Central  Google Scholar 

  36. Gerhart, J., Wu, M. & Kirschner, M. J. Cell Biol. 98, 1247–1255 (1984).

    CAS  PubMed  Google Scholar 

  37. Birchmeier, C., Brock, D. & Wigler, M. Cell 43, 615–621 (1985).

    CAS  PubMed  Google Scholar 

  38. Murray, A. & Kirschner, M. Science 246, 614–621 (1989).

    ADS  CAS  PubMed  Google Scholar 

  39. Lohka, M. J., Hayes, M. K. & Maller, J. L. Proc. natn. Acad. Sci. U.S.A. 85, 3009–3013 (1988).

    ADS  CAS  Google Scholar 

  40. Gautier, J., Norbury, C., Lohka, M., Nurse, P. & Maller, J. Cell 54, 433–439 (1988).

    CAS  PubMed  Google Scholar 

  41. Dunphy, W. G., Brizuela, L., Beach, D. & Newport, J. Cell 54, 423–431 (1988).

    CAS  PubMed  Google Scholar 

  42. Labbe, J. C., Lee, M. G., Nurse, P., Picard, A. & Doree, M. Nature 335, 251–254 (1988).

    ADS  CAS  PubMed  Google Scholar 

  43. Labbe, J. C. et al. Cell 57, 253–263 (1989).

    CAS  PubMed  Google Scholar 

  44. Evans, T., Rosenthal, E., Youngbloom, J., Distel, D. & Hunt, T. Cell 33, 389–396 (1983).

    CAS  PubMed  Google Scholar 

  45. Hunt, T. Curr. Op. Cell Biol. 1, 268–274 (1989).

    CAS  PubMed  Google Scholar 

  46. Swenson, K. I., Farrell, K. M. & Ruderman, J. V. Cell 47, 861–870 (1986).

    CAS  PubMed  Google Scholar 

  47. Murray, A. W. & Kirschner, M. W. Nature 339, 275–280 (1989).

    ADS  CAS  PubMed  Google Scholar 

  48. Minshull, J., Blow, J. & Hunt, T. Cell 56, 947–956 (1989).

    CAS  PubMed  Google Scholar 

  49. Draetta, G., Luca, F., Westendorf, J., Brizuela, L., Ruderman, J. & Beach, D. Cell 56, 829–838 (1989).

    CAS  PubMed  Google Scholar 

  50. Labbe, J.-C. et al. EMBO J. 8, 3052–3058 (1989).

    Google Scholar 

  51. Booher, R. & Beach, D. EMBO J. 7, 2321–2327 (1988).

    CAS  PubMed  PubMed Central  Google Scholar 

  52. Solomon, M., Booher, R., Kirschner, M. & Beach, D. Cell 54, 738 (1988).

    CAS  Google Scholar 

  53. Lee, M. G. & Nurse, P. Nature 327, 31–35 (1987).

    ADS  CAS  PubMed  Google Scholar 

  54. Draetta, G., Brizuela, L., Potashkin, J. & Beach, D. Cell 50, 319–325 (1987).

    CAS  PubMed  Google Scholar 

  55. Riabowol, K., Draetta, G., Brizuela, L., Vandre, D. & Beach, D. Cell 57, 393–401 (1989).

    CAS  PubMed  Google Scholar 

  56. Pines, J. & Hunter, T. Cell 58, 833–846 (1989).

    CAS  PubMed  Google Scholar 

  57. Langan, T. Methods Cell Biol. 19, 127–142 (1978).

    CAS  PubMed  Google Scholar 

  58. Langan, T. A. et al. Molec. cell. Biol. 9, 3860–3868 (1989).

    CAS  PubMed  PubMed Central  Google Scholar 

  59. Bradbury, E. M., Inglis, R. J. & Matthews, H. R. Nature 247, 257–261 (1974).

    ADS  CAS  PubMed  Google Scholar 

  60. Bradbury, E., Inglis, R., Matthews, H. & Langan, T. Nature 249, 553–556 (1974).

    ADS  CAS  PubMed  Google Scholar 

  61. Gautier, J., Matsukawa, T., Nurse, P. & Maller, J. Nature 339, 626–629 (1989).

    ADS  CAS  PubMed  Google Scholar 

  62. Draetta, G. & Beach, D. Cell 54, 17–26 (1988).

    CAS  PubMed  Google Scholar 

  63. Inglis, R., Langan, T., Matthews, H., Hardie, D. & Bradbury, E. Expl. Cell Res. 97, 418–425 (1976).

    CAS  Google Scholar 

  64. Nurse, P. Biochem. Soc. Trans. 569th Meeting, Sussex, 1191–1193 (1977).

  65. Morla, A. O., Draetta, G., Beach, D. & Wang, J. Y. L. Cell 58, 193–203 (1989).

    CAS  PubMed  Google Scholar 

  66. Gould, K. L. & Nurse, P. Nature 342, 39–45 (1989).

    ADS  CAS  PubMed  Google Scholar 

  67. Draetta, G. et al. Nature 336, 738–743 (1988).

    ADS  CAS  PubMed  Google Scholar 

  68. Dunphy, W. G. & Newport, J. W. Cell 58, 181–191 (1989).

    CAS  PubMed  Google Scholar 

  69. Moreno, S., Nurse, P. & Russell, R. Nature 344, 549–552 (1990).

    ADS  CAS  PubMed  Google Scholar 

  70. Felix, M., Pines, J., Hunt, T. & Karsenti, E. EMBO J. 8, 3059–3069 (1989).

    CAS  PubMed  PubMed Central  Google Scholar 

  71. Cyert, M. & Kirschner, M. Cell 53, 185–195 (1988).

    CAS  PubMed  Google Scholar 

  72. Murray, A. W., Solomon, M. J. H. & Kirschner, M. W. Nature 339, 280–286 (1989).

    ADS  CAS  PubMed  Google Scholar 

  73. Lehner, C. F. & O'Farrell, P. H. Cell 56, 957–968 (1989).

    CAS  PubMed  PubMed Central  Google Scholar 

  74. O'Farrell, P., Edgar, B., Lakich, D. & Lehner, C. Science 246, 635–640 (1989).

    ADS  CAS  PubMed  Google Scholar 

  75. Ford, C. C. J. Embryol. exp. Morph. 89 Suppl., 271–284 (1985).

    PubMed  Google Scholar 

  76. Reed, S., Hadwiger, J. & Lorincz, A. Proc. natn. Acad. Sci. U.S.A. 82, 4055–4059 (1985).

    ADS  CAS  Google Scholar 

  77. Shenoy, S. et al. Cell 57, 763–774 (1989).

    CAS  PubMed  Google Scholar 

  78. Morgan, D. O., Kaplan, J. M., Bishop, J. M. & Varmus, H. E. Cell 57, 775–786 (1989).

    CAS  PubMed  Google Scholar 

  79. Cisek, L. & Cofden, J. Nature 339, 679–684 (1989).

    ADS  CAS  PubMed  Google Scholar 

  80. McVey, D., Brizuela, L., Mohr, I., Mashak, D. R., Gluzman, Y. & Beach, D. Nature 341, 503–507 (1989).

    ADS  CAS  PubMed  Google Scholar 

  81. Belle, R., Derancourt, J., Poulhe, R., Capony, J., Ozon, R. & Mulner-Lorillon, D. FEBS Lett. 255, 101–104 (1989).

    CAS  PubMed  Google Scholar 

  82. Suzuki, M. J. molec. Biol. 207, 61–84 (1989).

    CAS  PubMed  Google Scholar 

  83. Hanks, S. K., Quinn, A. M. & Hunter, T. Science 241, 42–52 (1988).

    ADS  CAS  PubMed  Google Scholar 

  84. Gerace, L. & Burke, B. A. Rev. Cell. Biol. 4, 335–374 (1988).

    CAS  Google Scholar 

  85. Bailly, E., Doree, M., Nurse, P. & Bornens, M. EMBO J. 8, 3985–3995 (1989).

    CAS  PubMed  PubMed Central  Google Scholar 

  86. Akhurst, R. J., Flavin, N. B., Worden, J. & Lee, M. G. Differentiation 40, 36–41 (1989).

    CAS  PubMed  Google Scholar 

  87. Ohkura, H., Kinoshita, N., Miyatani, S., Toda, T. & Yanagida, M. Cell 57, 997–1007 (1989).

    CAS  PubMed  Google Scholar 

  88. Booher, R. & Beach, D. Cell 57, 1009–1016 (1989).

    CAS  PubMed  Google Scholar 

  89. Doonan, J. H. & Morris, N. R. Cell 57, 987–996 (1989).

    CAS  PubMed  Google Scholar 

  90. Norbury, C. & Nurse, P. Biochim. biophys. Acta 989, 85–95 (1989).

    CAS  PubMed  Google Scholar 

  91. Russell, P., Moreno, S. & Reed, S. I. Cell 57, 295–303 (1989).

    CAS  PubMed  Google Scholar 

  92. Edgar, B. A. & O'Farrell, P. H. Cell 57, 177–187 (1989).

    CAS  PubMed  PubMed Central  Google Scholar 

  93. Enoch, T. & Nurse, P. Cell 60, 665–673 (1990).

    CAS  PubMed  Google Scholar 

  94. Weinert, T. A. & Hartwell, L. H. Science 241, 317–322 (1988).

    ADS  CAS  PubMed  Google Scholar 

  95. Osmani, S., Engle, D., Doonan, J. & Morris, N. Cell 52, 241–251 (1988).

    CAS  PubMed  Google Scholar 

  96. Osmani, S., Pu, R. & Morris, N. Cell 53, 237–244 (1988).

    CAS  PubMed  Google Scholar 

  97. Nishimoto, T., Eilen, E. & Basilico, C. Cell 15, 475–483 (1978).

    CAS  PubMed  Google Scholar 

  98. Sluder, G. & Lewis, K. J. exp. Zool. 244, 89–100 (1987).

    CAS  PubMed  Google Scholar 

  99. Raff, J. & Glover, D. J. Cell Biol. 107, 2009–2019 (1988).

    CAS  PubMed  Google Scholar 

  100. Tyson, J. & Kauffman, S. J. math. Biol. 1, 289–310 (1975).

    Google Scholar 

  101. Tyson, J. J. J. theor. Biol. 126, 381–391 (1987).

    CAS  PubMed  Google Scholar 

  102. Nurse, P. in DNA and Evolution: Natural Selection and Genome Size (ed. Cavalier-Smith, T.) 185–196 (Wiley, Chichester, 1985).

    Google Scholar 

  103. Kacser, H. & Burns, J. Symp. Soc. exp. Biol. 27, 65–107 (1973).

    CAS  PubMed  Google Scholar 

  104. John, P., Sek, F. & Lee, M. The Plant Cell 1, 1185–1193 (1989).

    CAS  PubMed  PubMed Central  Google Scholar 

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  1. ICRF Cell Cycle Group, Department of Biochemistry, University of Oxford, South Parks Road, Oxford, 0X1 3QU, UK

    Paul Nurse

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Nurse, P. Universal control mechanism regulating onset of M-phase. Nature 344, 503–508 (1990). https://doi.org/10.1038/344503a0

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