Abstract
IRRADIATED MHC-heterozygous mice often reject bone marrow cells transplanted from one of the homozygous parental strains, a phenomenon ('hybrid resistance') that appears to violate the laws of transplantation1,2. Rejection of parental and allogeneic marrow cells also differs from conventional T cell-mediated rejection mechanisms as it is effected by NK1.1+cells3–5. To account for the unusual specificity of bone marrow rejection, it has been proposed that NK1.1+ cells destroy marrow cells that fail to express the full complement of self MHC class I (MHC-I) molecules5. We show here that NK1.1+ cells in normal mice reject haemopoietic transplants from mice that are deficient for normal cell-surface MHC-I expression because of a targeted mutation in the β2-microglobulin gene6–9. These findings demonstrate that deficient expression of MHC-I molecules renders marrow cells susceptible to rejection.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Cudkowicz, G. & Stimpfling, J. H. Nature 204, 450–453 (1964).
Cudkowicz, G. & Bennett, M. J. Exp. Med. 134, 1513–1528 (1971).
Murphy, W. J., Kumar, V. & Bennett, M. J. exp. Med. 166, 1499–1509 (1987).
Yankelevich, B., Knobloch, C., Nowicki, M. & Dennert, G. J. Immun. 142, 3423–3430 (1989).
Ohlen, C. et al. Science 246, 666–668 (1989).
Zijlstra, M., Li, E., Sajjadi, F., Subramani, S. & Jaenisch, R. Nature 342, 435–438 (1989).
Zijlstra, M. et al. Nature 344, 742–746 (1990).
Koller, B. H. & Smithies, O. Proc. natn. Acad. Sci. U.S.A. 86, 8932–8935 (1989).
Koller, B. H., Marrack, P., Kappler, J. W. & Smithies, O. Science 248, 1227–1230 (1990).
Klein, J., Flaherty, L., VandeBerg, J. L. & Schreffler, D. C. Immunogenetics 6, 489–512 (1978).
Koo, G. C., Dumont, F. J., Tutt, M., Hackett, J. Jr & Kumar, V. J. Immun. 137, 3742–3747 (1986).
Kiessling, R. et al. Eur. J. Immun. 7, 655–663 (1977).
Murphy, W., Kumar, V. & Bennett, M. J. exp. Med. 165, 1212–1217 (1987).
Herberman, R. B. & Ortaldo, J. R. Science 214, 24–30 (1981).
Dennert, G., Knobloch, C., Sugawara, S. & Yankelevich, B. Immunogenetics 31, 161–168 (1990).
Storkus, W. J., Howell, D. N., Salter, R. D., Dawson, J. R. & Cresswell, P. J. Immun. 138, 1657–1659 (1987).
Shimuzu, Y. & DeMars, R. Eur. J. Immun. 19, 447–451 (1989).
Stumhöfel, K. & Hämmerling, G. J. Eur. J. Immun. 20, 171–177 (1990).
Harel-Bellan, A. et al. Proc. natn. Acad. Sci. U.S.A. 83, 5688 (1986).
Kärre, K., Ljunggren, H. G., Piontek, G. & Kiessling, R. Nature 319, 675–678 (1986).
Cudkowicz, G. & Lotzova, E. Transplant. Proc. 4, 1399 (1973).
Rembecki, R. M., Bennett, M., Kumar, V. & Potter, T. A. J. Immun. 138, 2734–2738 (1987).
Schrier, P. I., Bernards, R., Vaessen, R. T. M. J., Houweling, A. & van der Eb, A. J. Nature 305, 771–775 (1983).
Höglund, P. et al. J. exp. Med. 168, 1469–1474 (1988).
Liao, N.-S., Maltzman, J. & Raulet, D. H. J. exp. Med. 170, 135–143 (1989).
Fowlkes, B. J., Edison, L., Mathieson, B. J. & Chused, T. M. J. exp. Med. 162, 802–822 (1985).
Stallcup, K. C., Springer, T. A. & Mescher, M. F. J. Immun. 127, 923–930 (1981).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Bix, M., Liao, NS., Zijlstra, M. et al. Rejection of class I MHC-deficient haemopoietic cells by irradiated MHC-matched mice. Nature 349, 329–331 (1991). https://doi.org/10.1038/349329a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/349329a0
This article is cited by
-
Chimeric antigen receptor-natural killer cells: a promising sword against insidious tumor cells
Human Cell (2023)
-
VCAM1 confers innate immune tolerance on haematopoietic and leukaemic stem cells
Nature Cell Biology (2022)
-
Immune reaction and regulation in transplantation based on pluripotent stem cell technology
Inflammation and Regeneration (2020)
-
Generation and characterization of HLA-universal platelets derived from induced pluripotent stem cells
Scientific Reports (2020)
-
NK cell recognition of hematopoietic cells by SLAM-SAP families
Cellular & Molecular Immunology (2019)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.