Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Involvement of p34cdc2 in establishing the dependency of S phase on mitosis

Nature volume 349, pages 388–393 (1991)Cite this article

Abstract

Mutants of cdc2+ can disrupt the dependency of S phase on completion of the previous mitosis. By changing the state of p34cdc2 it is possible to reprogramme a cell from entering mitosis to undergoing S phase. This leads to the proposal that the cell cycle can be considered a p34cdc2 cycle, and has implications for the evolution of life cycles.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Mitchison, J. M. in The Biology of the Cell Cycle, 201–249 (Cambridge University Press, 1971).

    Google Scholar 

  2. Hartwell, L. & Weinert, T. Science 246, 629–634 (1989).

    Article  ADS  CAS  PubMed  Google Scholar 

  3. Beermann, W. in Developmental Studies on Giant Chromosomes, 1–33 (Springer Verlag, New York, 1972).

    Google Scholar 

  4. Sluder, G., Miller, F. & Spanjian, K. J. exp. Zool. 238, 325–336 (1986).

    Article  CAS  PubMed  Google Scholar 

  5. Hara, K., Tydman, P. & Kirschner, M. Proc. natn. Acad. Sci. U.S.A. 77, 462–466 (1980).

    Article  ADS  CAS  Google Scholar 

  6. Picard, A., Harricane, M.-C., Labbé, J.-C. & Dorée, M. Devl Biol. 128, 121–128 (1988).

    Article  CAS  Google Scholar 

  7. Kimelman, D. Kirschner, M. & Scherson, T. Cell 48, 399–407 (1987).

    Article  CAS  PubMed  Google Scholar 

  8. Simanis, V. & Nurse, P. Cell 45, 261–268 (1986).

    Article  CAS  PubMed  Google Scholar 

  9. Moreno, S., Hayles, J. & Nurse, P. Cell 58, 361–372 (1989).

    Article  CAS  PubMed  Google Scholar 

  10. Russell, P. & Nurse, P. Cell 45, 145–153 (1986).

    Article  CAS  PubMed  Google Scholar 

  11. Moreno, S., Nurse, P. & Russell, P. Nature 344, 549–552 (1990).

    Article  ADS  CAS  PubMed  Google Scholar 

  12. Enoch, T. & Nurse, P. Cell 60, 665–673 (1990).

    Article  CAS  PubMed  Google Scholar 

  13. Nurse, P. & Bissett, Y. Nature 292, 558–560 (1981).

    Article  ADS  CAS  PubMed  Google Scholar 

  14. Bartlett, R. & Nurse, P. Bioessays 10, 457–463 (1990).

    Article  Google Scholar 

  15. Nurse, P. Nature 344, 503–508 (1990).

    Article  ADS  CAS  PubMed  Google Scholar 

  16. Gould, K. & Nurse, P. Nature 342, 39–45 (1989).

    Article  ADS  CAS  PubMed  Google Scholar 

  17. Dasso, M. & Newport, J. Cell 61, 811–823 (1990).

    Article  CAS  PubMed  Google Scholar 

  18. Schlegel, R. & Pardee, A. Science 232, 1264–1266 (1986).

    Article  ADS  CAS  PubMed  Google Scholar 

  19. Nishimoto, T., Eilen, E. & Basilico, C. Cell 15, 475–483 (1978).

    Article  CAS  PubMed  Google Scholar 

  20. Kai, R., Ohtsubo, M., Sekiguchi, M. & Nishimoto, T. Molec. Cell. Biol. 6, 2027–2032 (1986).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Osmani, S., Engle, D., Doonan, J. & Morris, N. Cell 52, 241–251 (1988).

    Article  CAS  PubMed  Google Scholar 

  22. Osmani, S., Pu, R. & Morris, N. Cell 53, 237–244 (1988).

    Article  CAS  PubMed  Google Scholar 

  23. Weinert, T. & Hartwell, L. Science, 241, 317–322 (1988).

    Article  ADS  CAS  PubMed  Google Scholar 

  24. Pringle, J. & Hartwell, L. in The Molecular Biology of the Yeast Saccharomyces. Life Cycle and Inheritance (eds Strathern, J., Jones, E. & Broach, J.) 97–142 (Cold Spring Harbor Laboratory, New York, 1981).

    Google Scholar 

  25. Uemura, T. & Yanagida, M. EMBO J. 5, 1003–1010 (1986).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Rao, P. & Johnson, R. Nature 225, 159–164 (1970).

    Article  ADS  CAS  PubMed  Google Scholar 

  27. Freeman, M. & Glover, D. Genes Dev. 1, 924–930 (1987).

    Article  CAS  PubMed  Google Scholar 

  28. Brewer, E. & Rusch, H. Expl Cell Res. 49, 79–86 (1968).

    Article  CAS  Google Scholar 

  29. Roberts, J. & Weintraub, H. Cell 452, 397–404 (1988).

    Article  Google Scholar 

  30. Blow, J. & Laskey, R. Nature 332, 546–548 (1988).

    Article  ADS  CAS  PubMed  Google Scholar 

  31. Murray, A. Nature 342, 14–15 (1989).

    Article  ADS  CAS  PubMed  Google Scholar 

  32. Egel, R. in Molecular Biology of the Fission Yeast, 31–73. (Academic, New York, 1989).

    Book  Google Scholar 

  33. Egel, R. Molec. gen. Genet. 122, 339–343 (1973).

    Article  CAS  PubMed  Google Scholar 

  34. Crandall, M., Egel, R. & MacKay, V. Adv. microb. Physiol. 15, 307–398 (1977).

    Article  CAS  PubMed  Google Scholar 

  35. Moreno, S., Klar, A. & Nurse, P. Meth. Enzym. 194, 793–823 (1990).

    Google Scholar 

  36. Hirano, T., Funahashi, S., Uemura, T. & Yanagida, M. EMBO J. 5, 2973–2979 (1986).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  37. Baum, P., Yip, C., Goetsch, L. & Byers, B. Molec. cell. Biol. 8, 5386–5397 (1988).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. Nurse, P. Thuriaux, P. & Nasmyth, K. Molec. gen. Genet. 146, 167–178 (1976).

    Article  CAS  PubMed  Google Scholar 

  39. Nurse, P. & Thuriaux, P. Genetics 96, 627–637 (1980).

    CAS  PubMed  PubMed Central  Google Scholar 

  40. Carr, A., MacNeill, S., Hayles, J. & Nurse, P. Molec. gen. Genet. 218, 41–49 (1989).

    Article  CAS  PubMed  Google Scholar 

  41. Bostock, C. Expl Cell Res. 60, 16–26 (1970).

    Article  CAS  Google Scholar 

  42. Costello, G., Rodgers, L. & Beach, D. Curr. Genet. 11, 119–125 (1986).

    Article  Google Scholar 

  43. Nasmyth, K. & Nurse, P. Molec. gen. Genet. 182, 119–124 (1981).

    Article  CAS  PubMed  Google Scholar 

  44. Booher, R. & Beach, D. EMBO J. 7, 2321–2327 (1988).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  45. Morla, A., Draetta, G., Beach, D. & Wang, J. Cell 58, 193–203 (1989).

    Article  CAS  PubMed  Google Scholar 

  46. Booher, R., Alfa, C., Hyams, J. & Beach, D. Cell. 58, 485–497 (1989).

    Article  CAS  PubMed  Google Scholar 

  47. Hunt, T. Curr. Op. Cell Biol. 1, 268–274 (1989).

    Article  CAS  PubMed  Google Scholar 

  48. Hagan, I., Hayles, J. & Nurse, P. J. Cell Sci. 91, 587–595 (1988).

    CAS  PubMed  Google Scholar 

  49. Yoshida, M. et al. Expl Cell Res. 187, 150–156 (1990).

    Article  CAS  Google Scholar 

  50. Mitchison, J. M. in Methods in Physiology Vol. 4, 131–165 (Academic, New York, 1970).

    Google Scholar 

  51. Nurse, P. Nature 256, 547–551 (1975).

    Article  ADS  CAS  PubMed  Google Scholar 

  52. Kohli, J., Hottinger, H., Munz, P., Strauss, A. & Thuriaux, P. Genetics 87, 471 (1977).

    CAS  PubMed  PubMed Central  Google Scholar 

  53. Roman, H., Phillips, M. & Sands, S. Genetics, 40, 546–561 (1955).

    CAS  PubMed  PubMed Central  Google Scholar 

  54. Gendimenico, G., Bouquin, P. & Tramposch, K. Analyt. Biochem. 173, 45–48 (1988).

    Article  CAS  PubMed  Google Scholar 

  55. Sazer, S. & Sherwood, S. J. Cell Sci. 97, 509–516 (1990).

    CAS  PubMed  Google Scholar 

  56. Hill, H. & Straka, J. Analyt. Biochem. 170, 203–208 (1988).

    Article  CAS  PubMed  Google Scholar 

  57. Laemmli, U. Nature 227, 680–685 (1970).

    Article  ADS  CAS  PubMed  Google Scholar 

  58. Towbin, H., Staehelin, T. & Gordon, J. Proc. natn. Acad. Sci. U.S.A. 76, 4350–4354 (1979).

    Article  ADS  CAS  Google Scholar 

  59. Leary, J., Brigati, D. & Ward, D. Proc. natn. Acad. Sci. U.S.A. 80, 4045–4049 (1983).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Author notes

  1. Daniel Broek

    Present address: Department of Biochemistry, Norris Cancer Research Institute, University of Southern California, School of Medicine, Los Angeles, California, 90014, USA

  2. Paul Nurse: To whom correspondence should be addressed.

Authors and Affiliations

  1. ICRF Cell Cycle Group, Microbiology Unit, Biochemistry Department, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK

    Daniel Broek, Rachel Bartlett, Kevin Crawford & Paul Nurse

Authors
  1. Daniel Broek
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Rachel Bartlett
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Kevin Crawford
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Paul Nurse
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Broek, D., Bartlett, R., Crawford, K. et al. Involvement of p34cdc2 in establishing the dependency of S phase on mitosis. Nature 349, 388–393 (1991). https://doi.org/10.1038/349388a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/349388a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing