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The chemotactic receptor for human C5a anaphylatoxin

Nature volume 349, pages 614–617 (1991)Cite this article

Abstract

HOST defence and inflammatory responses are controlled and amplified by receptor-mediated events often initiated by a chemotactic factor that directs the approach of phagocytic cells1. Complement receptors CR1 and CR3 are responsible for the phagocytic and adhesive properties of neutrophils 2,3, whereas the C5a receptor mediates the pro-inflammatory and chemotactic actions of the complement anaphylatoxin CSa4–6. In addition to stimulating chemotaxis, granule enzyme release and superoxide anion production, this receptor stimulates upregulation of expression and activity of the adhesion molecule MAC-1, and of CR1, and a decrease in cell-surface glycoprotein 1 GOMEL-14 on neutrophils7–9. In vivo, the C5a receptor may participate in anaphylactoid and septic shock 10–12. The human C5a receptor was cloned from U937 and HL-60 cells and identified by high affinity binding when expressed in COS-7 cells. The deduced amino-acid sequence of the receptor reveals the expected motifs befitting its interaction with cellular GTP-binding proteins.

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Authors and Affiliations

  1. Ina Sue Perlmutter Research Laboratory, Childrens' Hospital, Pulmonary Division, Beth Israel Hospital, Departments of Medicine and Pediatrics, Harvard Medical School, Boston, Massachusetts, 02115, USA

    Norma P. Gerard & Craig Gerard

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  1. Norma P. Gerard
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  2. Craig Gerard
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Gerard, N., Gerard, C. The chemotactic receptor for human C5a anaphylatoxin. Nature 349, 614–617 (1991). https://doi.org/10.1038/349614a0

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