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Molecular cloning and characterization of the rat NMDA receptor

Nature volume 354, pages 31–37 (1991)Cite this article

Abstract

A complementary DNA encoding the rat NMDA receptor has been cloned and characterized. The single protein encoded by the cDNA forms a receptor-channel complex that has electrophysiological and pharmacological properties characteristic of the NMDA receptor. This protein has a significant sequence similarity to the AMPA/kainate receptors and contains four putative transmembrane segments following a large extracellular domain. The NMDA receptor messenger RNA is expressed in neuronal cells throughout the brain regions, particularly in the hippocampus, cerebral cortex and cerebellum.

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Authors and Affiliations

  1. Institute for Immunology, Kyoto University Faculty of Medicine, Kyoto, 606, Japan

    Koki Moriyoshi, Masayuki Masu, Takahiro Ishii & Shigetada Nakanishi

  2. Department of Morphological Brain Science, Kyoto University Faculty of Medicine, Kyoto, 606, Japan

    Ryuichi Shigemoto & Noboru Mizuno

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  1. Koki Moriyoshi
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  2. Masayuki Masu
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  3. Takahiro Ishii
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  4. Ryuichi Shigemoto
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  5. Noboru Mizuno
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  6. Shigetada Nakanishi
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Moriyoshi, K., Masu, M., Ishii, T. et al. Molecular cloning and characterization of the rat NMDA receptor. Nature 354, 31–37 (1991). https://doi.org/10.1038/354031a0

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