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ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex

Nature volume 357, pages 128–134 (1992)Cite this article

Abstract

A multiprotein complex that specifically recognizes cellular origins of DNA replication has been identified and purified from the yeast Saccharomyces cerevisiae. We observe a strong correlation between origin function and origin recognition by this activity. Interestingly, specific DNA binding by the origin recognition complex is dependent upon the addition of ATP. We propose that the origin recognition complex acts as the initiator protein for S. cerevisiae origins of DNA replication.

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Authors and Affiliations

  1. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, 11724, USA

    Stephen P. Bell & Bruce Stillman

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  1. Stephen P. Bell
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  2. Bruce Stillman
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Bell, S., Stillman, B. ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex. Nature 357, 128–134 (1992). https://doi.org/10.1038/357128a0

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