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Regulation of progression through the Gl phase of the cell cycle by the rum1+ gene

Nature volume 367, pages 236–242 (1994)Cite this article

Abstract

The rum1+ gene is identified as a new regulator of Gl progression in fission yeast. It influences three aspects of Gl regulation: determination of the length of Gl, dependence of S phase upon completion of mitosis, and restraint of mitosis until Gl is finished. We propose that it has a central role in regulating the Gl phase of the cell cycle.

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References

  1. Nurse, P. Nature 256, 547–551 (1975).

    Article  ADS  CAS  Google Scholar 

  2. Nurse, P. & Thuriaux, P. Expl Cell Res. 107, 365–375 (1977).

    Article  CAS  Google Scholar 

  3. Nasmyth, K., Nurse, P. & Fraser, R. J. Cell Sci. 39, 215–233 (1979).

    CAS  PubMed  Google Scholar 

  4. Nurse, P., Thuriaux, P. & Nasmyth, K. Molec. gen. Genet 146, 167–178 (1976).

    Article  CAS  Google Scholar 

  5. Hartwell, L. Bact. Rev. 38, 164–198 (1974).

    CAS  PubMed  Google Scholar 

  6. Hartwell, L. & Unger, M. J. Cell. Biol. 75, 422–435 (1977).

    Article  CAS  Google Scholar 

  7. Nurse, P. & Bissett, Y. Nature 292, 558–560 (1981).

    Article  ADS  CAS  Google Scholar 

  8. Lowndes, N., Mclnerny, L., Johnson, A., Fantes, P. & Johnston, L. Nature 355, 449–452 (1992).

    Article  ADS  CAS  Google Scholar 

  9. Tanaka, K. et al. EMBO J. 11, 4923–4932 (1992).

    Article  CAS  Google Scholar 

  10. Caligiuri, M. & Beach, D. Cell 72, 607–619 (1993).

    Article  CAS  Google Scholar 

  11. Broek, D., Bartlett, R., Crawford, K. & Nurse, P. Nature 349, 388–393 (1991).

    Article  ADS  CAS  Google Scholar 

  12. Maundrell, K. J. biol. Chem. 265, 10857–10864 (1989).

    Google Scholar 

  13. Thuriaux, P., Sipiczki, M. & Fantes, P. A. J. gen. Microbiol. 116, 525–528 (1980).

    CAS  PubMed  Google Scholar 

  14. Egel, R., Nielsen, O. & Weilguny, D. Trends Genet. 6, 369–373 (1990).

    Article  CAS  Google Scholar 

  15. Nurse, P. & Thuriaux, P. Genetics 96, 627–637 (1980).

    CAS  PubMed  PubMed Central  Google Scholar 

  16. Uemura, T. & Yanagida, M. EMBO J. 3, 1737–1744 (1984).

    Article  CAS  Google Scholar 

  17. Hirano, T., Funahashi, S., Uemura, T. & Yanagida, M. EMBO J. 5, 2973–2979 (1986).

    Article  CAS  Google Scholar 

  18. Enoch, T. & Nurse, P. Cell 60, 665–673 (1990).

    Article  CAS  Google Scholar 

  19. Enoch, T., Carr, A. & Nurse, P. Genes Dev. 6, 2035–2046 (1992).

    Article  CAS  Google Scholar 

  20. Hartwell, L. & Weinert, T. Science 246, 629–634 (1989).

    Article  ADS  CAS  Google Scholar 

  21. Murray, A. Nature 359, 599–604 (1992).

    Article  ADS  CAS  Google Scholar 

  22. Kalderon, D., Richardson, W. D., Markham, A. F. & Smith, A. E. Nature 311, 33–38 (1984).

    Article  ADS  CAS  Google Scholar 

  23. Robbins, J., Dilworth, S. M., Laskey, R. A. & Dingwall, C. Cell 64, 615–623 (1991).

    Article  CAS  Google Scholar 

  24. Moreno, S. & Nurse, P. Cell 61, 549–551 (1990).

    Article  CAS  Google Scholar 

  25. Clarke-Lewis, I., Sanghera, J. S. & Pelech, S. L. J. biol. Chem. 266, 15180–15184 (1991).

    Google Scholar 

  26. Sudbery, P. E., Goodey, A. R. & Carter, B. L. A. Nature 288, 401–404 (1980).

    Article  ADS  CAS  Google Scholar 

  27. Nash, R., Tokiwa, G., Anand, S., Erickson, K. & Futcher, A. B. EMBO J. 7, 4335–4346 (1988).

    Article  CAS  Google Scholar 

  28. Cross, F. Molec. cell. Biol. 8, 4675–4684 (1988).

    Article  CAS  Google Scholar 

  29. Hadwiger, J. A., Wittenberg, C., Richardson, H. E., De Barros Lopes, M. & Reed, S. I. Proc. natn. Acad. Sci. U.S.A. 86, 6255–6259 (1989).

    Article  ADS  CAS  Google Scholar 

  30. Ohtsubo, M. & Roberts, J. M. Science 259, 1908–1912 (1993).

    Article  ADS  CAS  Google Scholar 

  31. Smith, A. V. & Orr-Weaver, T. L. Development 112, 997–1008 (1991).

    CAS  PubMed  Google Scholar 

  32. Blow, J. J. & Laskey, R. A. Nature 332, 546–548 (1988).

    Article  ADS  CAS  Google Scholar 

  33. Handeli, S. & Weintraub, H. Cell 71, 599–611 (1992).

    Article  CAS  Google Scholar 

  34. Kelly, T. J. et al. Cell 74, 371–382 (1993).

    Article  CAS  Google Scholar 

  35. Saka, Y. & Yanagida, M. Cell 74, 383–393 (1993).

    Article  CAS  Google Scholar 

  36. Nurse, P. Nature 344, 503–508 (1990).

    Article  ADS  CAS  Google Scholar 

  37. Moreno, S., Klar, A. & Nurse, P. Meth. Enzym. 194, 795–823 (1991).

    Article  CAS  Google Scholar 

  38. Hofer, F. et al. Curr. Genet. 1, 45–61 (1979).

    Article  CAS  Google Scholar 

  39. Carr, A. M., MacNeill, S. A., Hayles, J. & Nurse, P. Molec. gen. Genet. 218, 41–49 (1989).

    Article  CAS  Google Scholar 

  40. Sazer, S. & Sherwood, S. W. J. Cell Sci. 97, 509–516 (1990).

    CAS  PubMed  Google Scholar 

  41. Bostock, F. Expl Cell Res. 60, 16–26 (1970).

    Article  CAS  Google Scholar 

  42. Gendimenico, G. J., Bouquin, P. L. & Tramposch, K. M. Analyt. Biochem. 173, 45–48 (1988).

    Article  CAS  Google Scholar 

  43. Moreno, S., Hayles, J. & Nurse, P. Cell 58, 361–372 (1989).

    Article  CAS  Google Scholar 

  44. Hoheisel, J. D. et al. Cell 73, 109–120 (1993).

    Article  CAS  Google Scholar 

Download references

Author information

Author notes

  1. Sergio Moreno

    Present address: Institute de Microbiologia-Bioquimica, CSIC/ Universidad de Salamanca, Edificio Departamental, Campus Miguel de Unamuno, 37007, Salamanca, Spain

Authors and Affiliations

  1. ICRF Cell Cycle Group, Department of Biochemistry, Oxford University, Oxford, 0X1 1QU

    Sergio Moreno & Paul Nurse

  2. ICRF, PO Box 123, Lincoln's Inn Fields, London, WC2A 3PX, UK

    Sergio Moreno & Paul Nurse

Authors
  1. Sergio Moreno
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  2. Paul Nurse
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Moreno, S., Nurse, P. Regulation of progression through the Gl phase of the cell cycle by the rum1+ gene. Nature 367, 236–242 (1994). https://doi.org/10.1038/367236a0

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