Abstract
As key regulators of the cell cycle, the cyclin-dependent kinases must be tightly regulated by extra- and intracellular signals. The activity of cyclin-dependent kinases is controlled by four highly conserved biochemical mechanisms, forming a web of regulatory pathways unmatched in its elegance and intricacy.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Norbury, C. & Nurse, P. A. Rev. Biochem. 61, 441–470 (1992).
Nasmyth, K. Curr. Opin. Cell Biol. 5, 166–179 (1993).
Reed, S. I. Rev. Cell Biol. 8, 529–561 (1992).
Sherr, C. J. Cell 73, 1059–1065 (1993).
Kaffman, A., Herskowitz, I., Tjian, R. & O'Shea, E. K. Science 263, 1153–1156 (1994).
Schneider, K. R., Smith, R. L. & O'Shea, E. K. Science 266, 122–126 (1994).
Lew, J. et al. Nature 371, 423–426 (1994).
Tsai, L.-H., Delalle, I., Caviness, V. S., Chae, T. & Harlow, E. Nature 371, 419–423 (1994).
Espinoza, F. H., Ogas, J., Herskowitz, I. & Morgan, D. O. Science 266, 1388–1391 (1994).
Measday, V., Moore, L., Ogas, J., Tyers, M. & Andrews, B. Science 266, 1391–1395 (1994).
Valay, J. G., Simon, M. & Faye, G. J. molec. Biol. 234, 307–310 (1993).
De Bondt, H. L. et al. Nature 363, 595–602 (1993).
Morgan, D. O. & De Bondt, H. L. Curr. Opin. Cell Biol. 6, 239–246 (1994).
Kobayashi, H. et al. Molec. Biol. Cell 3, 1279–1294 (1992).
Lees, E. M. & Harlow, E. Molec. cell. Biol. 13, 1194–1201 (1993).
Glotzer, M., Murray, A. W. & Kirschner, M. W. Nature 349, 132–138 (1991).
Hershko, A. et al. J. biol. Chem. 269, 4940–4946 (1994).
Pines, J. & Hunter, T. Cell 58, 833–846 (1989).
Pines, J. & Hunter, T. Nature 346, 760–763 (1990).
Lew, D. J., Dulic, V. & Reed, S. I. Cell 66, 1197–1206 (1991).
Amon, A., Irniger, S. & Nasmyth, K. Cell 77, 1037–1050 (1994).
Amon, A., Tyers, M., Futcher, B. & Nasmyth, K. Cell 74, 993–1007 (1993).
Hoffman, I., Clarke, P. R., Marcote, M. J., Karsenti, E. & Draetta, G. EMBO J 12, 53–63 (1993).
Peeper, D. S. et al. EMBO J. 12, 1947–1954 (1993).
Dynlacht, B. D., Flores, O., Lees, J. A. & Harlow, E. Genes Dev. 8, 1772–1786 (1994).
Ducommun, B. et al. EMBO J. 10, 3311–3319 (1991).
Desai, D., Wessling, H. C., Fisher, R. P. & Morgan, D. O. Molec. cell. Biol. 15, 345–350 (1995).
Fesquet, D. et al. EMBO J. 12, 3111–3121 (1993).
Poon, R. Y. C., Yamashita, K., Adamczewski, J. P., Hunt, T. & Shuttleworth, J. EMBO J. 12, 3123–3132 (1993).
Solomon, M, J., Harper, J. W. & Shuttleworth, J. EMBO J. 12, 3133–3142 (1993).
Tassan, J.-P., Schultz, S. J., Bartek, J. & Nigg, E. A. J. Cell biol. 127, 467–478 (1994).
Poon, R. Y. C. et al. J. Cell Sci. 107, 2789–2799 (1994).
Fisher, R. P. & Morgan, D. O. Cell 78, 713–724 (1994).
Matsuoka, M., Kato, J., Fisher, R. P., Morgan, D. O. & Sherr, C. J. Molec. cell. Biol. 14, 7265–7275 (1994).
Makela, T. P. et al. Nature 371, 254–257 (1994).
Krek, W. & Nigg, E. A. EMBO J. 10, 305–316 (1991).
Gu, Y., Rosenblatt, J. & Morgan, D. O. EMBO J. 11, 3995–4005 (1992).
Brown, A. J., Jones, T. & Shuttleworth, J. Molec. Biol. Cell 5, 921–932 (1994).
Atherton-Fessler, S., Parker, L. L., Geahlen, R. L. & Piwnica-Worms, H. Molec. cell. Biol. 13, 1675–1685 (1993).
Solomon, M., Glotzer, M., Lee, T. H., Phillipe, M. & Kirschner, M. Cell 63, 1013–1024 (1990).
Parker, L. L. & Piwnica-Worms, H. Science 257, 1955–1957 (1992).
McGowan, C. H. & Russell, P. EMBO J. 12, 75–85 (1993).
Kornbluth, S., Sebastian, B., Hunter, T. & Newport, J. Molec. Biol. Cell 5, 273–282 (1994).
Atherton-Fessler, S. et al. Molec. Biol. Cell 5, 989–1001 (1994).
Coleman, T. R., Tang, Z. & Dunphy, W. G. Cell 72, 919–929 (1993).
Parker, L. L., Walter, S. A., Young, P. G. & Piwnica-Worms, H. Nature 363, 736–738 (1993).
Wu, L. & Russell, P. Nature 363, 738–741 (1993).
Tang, Z., Coleman, T. R. & Dunphy, W. G. EMBO J. 12, 3427–3436 (1993).
Dunphy, W. G. Trends Cell Biol. 4, 202–207 (1994).
Izumi, T. & Maller, J. L. Molec. Biol. Cell 4, 1337–1350 (1993).
Chang, F. & Herskowitz, I. Cell 63, 999–1011 (1990).
Peter, M., Gartner, A., Horecka, J., Ammerer, G. & Herskowitz, I. Cell 73, 747–60 (1993).
Peter, M. & Herskowitz, I. Science 265, 1228–1231 (1994).
Mendenhall, M. D. Science 259, 216–219 (1993).
Nugroho, T. T. & Mendenhall, M. D. Molec. cell. Biol. 14, 3320–3328 (1994).
Donovan, J. D., Toyn, J. H., Johnson, A. L. & Johnston, L. H. Genes Dev. 8, 1640–1653 (1994).
Harper, J. W., Adami, G. R., Wei, N., Keyomarsi, K. & Elledge, S. J. Cell 75, 805–816 (1993).
El-Deiry, W. S. et al. Cell 75, 817–825 (1993).
Xiong, Y. et al. Nature 366, 701–704 (1993).
Gu, Y., Turck, C. W. & Morgan, D. O. Nature 366, 707–710 (1993).
Noda, A., Ning, Y., Venable, S. F., Pereira-Smith, O. M. & Smith, J. R. Expl Cell Res. 211, 90–98 (1994).
Polyak, K. et al. Genes Dev. 8, 9–22 (1994).
Polyak, K. et al. Cell 78, 59–66 (1994).
Toyoshima, H. & Hunter, T. Cell 78, 67–74 (1994).
Serrano, M., Hannon, G. J. & Beach, D. Nature 366, 704–707 (1993).
Hannon, G. J. & Beach, D. Nature 371, 257–261 (1994).
Zhang, H., Hannon, G. J. & Beach, D. Genes Dev. 8, 1750–1758 (1994).
El-Deiry, W. S. et al. Cancer Res. 54, 1169–1174 (1994).
Dulic, V. et al. Cell 76, 1013–1023 (1994).
Kato, J., Matsuoka, M., Polyak, K., Massague, J. & Sherr, C. J. Cell 79, 487–496 (1994).
Firpo, E. J., Koff, A., Solomon, M. J. & Roberts, J. M. Molec. cell. Biol. 14, 4889–4901 (1994).
McKinney, J. D., Chang, F., Heintz, N. & Cross, F. R. Genes Dev. 7, 833–843 (1993).
Schwob, E., Bohm, T., Mendenhall, M. D. & Nasmyth, K. Cell 79, 233–244 (1994).
Parge, H. E., Arvai, A. S., Murtari, D. J., Reed, S. I. & Tainer, J. A. Science 262, 387–395 (1993).
Wang, T. C. et al. Nature 369, 669–671 (1994).
Bonetta, L. Nature 370, 180 (1994).
Wainwright, B. Nature Genet. 8, 3–5 (1994).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Morgan, D. Principles of CDK regulation. Nature 374, 131–134 (1995). https://doi.org/10.1038/374131a0
Issue Date:
DOI: https://doi.org/10.1038/374131a0
This article is cited by
-
The CDK4/6 inhibitor revolution — a game-changing era for breast cancer treatment
Nature Reviews Clinical Oncology (2024)
-
Tasmanian devil cathelicidins exhibit anticancer activity against Devil Facial Tumour Disease (DFTD) cells
Scientific Reports (2023)
-
Binding patterns of derivatives of fisetin and chrysin to the enzyme complex cyclin-dependent kinase 6/cyclin D
Theoretical Chemistry Accounts (2023)
-
Morphology, Histology, and Transcriptome Analysis of Gonadal Development in Octopus minor (Sasaki, 1920)
Marine Biotechnology (2023)
-
The clinical significance of cyclin B1 (CCNB1) in invasive breast cancer with emphasis on its contribution to lymphovascular invasion development
Breast Cancer Research and Treatment (2023)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.