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Principles of CDK regulation

Abstract

As key regulators of the cell cycle, the cyclin-dependent kinases must be tightly regulated by extra- and intracellular signals. The activity of cyclin-dependent kinases is controlled by four highly conserved biochemical mechanisms, forming a web of regulatory pathways unmatched in its elegance and intricacy.

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Morgan, D. Principles of CDK regulation. Nature 374, 131–134 (1995). https://doi.org/10.1038/374131a0

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