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Impairment of T-cell-dependent B-cell responses and B-l cell development in CD19-deficient mice

Nature volume 376, pages 352–355 (1995)Cite this article

Abstract

CD 19 is the hallmark differentiation antigen of the B lineage. Its early expression has implicated a role for CD 19 during the antigen-independent phases of B-cell development, whereas in mature B cells CD 19 can act synergistically with surface immunoglobulin to induce activation1. We have generated CD19-deficient mice and found that development of conventional B cells is unperturbed. However, mature CD19-/- B cells show a profound deficiency in responding to protein antigens that require T-cell help. This is accompanied by a lack of germinal centre formation and affinity maturation of serum antibodies. Thus CD 19 is crucial for both initial B-cell activation by T-cell-dependent antigens and the maturation and/or selection of the activated cells into the memory compartment. An impairment in ligand-driven selection may also be responsible for the observation of a striking reduction in the B-l (formerly Ly-1) B-cell subset, thought to develop under the control of self-antigens and bacterial antigens (reviewed in ref. 2).

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Author notes

  1. Jiirgen Roes

    Present address: University College London Medical School, Department of Medicine, Rayne Institute, 5 University Street, London, WC1E 6JJ, UK

Authors and Affiliations

  1. Institute for Genetics, University of Cologne, Weyertal 121, D-50931, Cologne, Germany

    Robert C. Rickert, Klaus Rajewsky & Jiirgen Roes

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  2. Klaus Rajewsky
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Rickert, R., Rajewsky, K. & Roes, J. Impairment of T-cell-dependent B-cell responses and B-l cell development in CD19-deficient mice. Nature 376, 352–355 (1995). https://doi.org/10.1038/376352a0

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