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Follicular dendritic cells and human immunodeficiency virus infectivity

Nature volume 377, pages 740–744 (1995)Cite this article

Abstract

LARGE amounts of human immunodeficiency virus (HIV) localize on follicular dendritic cells (FDC) in the follicles of secondary lymphoid tissues following viral infection1,2. During clinical latency, active viral infection occurs primarily at these sites3,4. As HIV on FDC is in the form of immune complexes5, some of which may be formed with neutralizing antibody, we investigated whether HIV on FDC is infectious. We report here that HIV on FDC is highly infectious. Furthermore, FDC can convert neutralized HIV into an infectious form even in the presence of a vast excess of neutralizing antibody. Thus FDC may provide a mechanism whereby HIV infection can continue in the presence of neutralizing antibody.

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References

  1. Racz, P., Tenner-Racz, K. & Schmidt, H. Acta path. microbiol. immun. Scand. (suppl.) 8, 16–23 (1989).

    CAS  Google Scholar 

  2. Biberfeld, P. et al. Cancer Detect. Prev. 12, 217–224 (1988).

    CAS  PubMed  Google Scholar 

  3. Pantaleo, G. et al. Nature 362, 355–358 (1993).

    Article  ADS  CAS  PubMed  Google Scholar 

  4. Embretson, J. et al. Nature 362, 359–362 (1993).

    Article  ADS  CAS  PubMed  Google Scholar 

  5. Fox, C. H. & Cottler-Fox, M. Immun. Today 13, 353–356 (1992).

    Article  CAS  PubMed  Google Scholar 

  6. Tenner-Racz, K. et al. in Accessory Cells in HIV and Other Retroviral Infections (eds Racz, P., Dijkstra, C. D. & Gluckman, J. C.) Vol. 1. 83–97 (Karger, Basel, 1991).

    Google Scholar 

  7. Tew, J. G., Mandel, T. E. & Miller, G. A. Aust. J. exp. Biol. med. Sci. 57, 401–414 (1979).

    Article  CAS  PubMed  Google Scholar 

  8. Szakal, A. K., Holmes, K. L. & Tew, J. G. J. Immun. 131, 1714–1727 (1983).

    CAS  PubMed  Google Scholar 

  9. Burton, G. F., Conrad, D. H., Szakal, A. K. & Tew, J. G. J. Immun. 150, 31–38 (1993).

    CAS  PubMed  Google Scholar 

  10. Chesebro, B. & Wehrly, K. J. Virol. 62, 3779–3788 (1988).

    CAS  PubMed  PubMed Central  Google Scholar 

  11. Gray, D., Kosco, M. H. & Stockinger, B. Int. Immun. 3, 141–148 (1991).

    Article  CAS  PubMed  Google Scholar 

  12. Tew, J. G., Greene, E. J. & Makoski, M. H. Cell Immun. 26, 141–152 (1976).

    Article  CAS  Google Scholar 

  13. Tew, J. G., Burton, G. F. & Szakal, A. K. in Handbook of Experimental Immunology: The Lymphoid System Antibody Responses and Affinity Maturation (ed. Nossal, G. J. V.) (Rockwell Scientific, Oxford, in the press).

  14. Butch, A., Chung G., Hoffmann, J. & Nahm, M. J. Immun. 150, 39–47 (1993).

    CAS  PubMed  Google Scholar 

  15. Butch, A. W., Hug, B. A. & Nahm, M. H. Cell Immun. 155, 27–41 (1994).

    Article  CAS  Google Scholar 

  16. Camron, P. U. et al. Science 257, 383–387 (1992).

    Article  ADS  Google Scholar 

  17. Ou, C. et al. Science 239, 295–297 (1988).

    Article  ADS  CAS  PubMed  Google Scholar 

  18. Bauer, H. M. et al. J. Am. med. Soc. 265, 472–477 (1991).

    CAS  Google Scholar 

  19. Clouse, K. A. et al. J. Immun. 142, 431–438 (1989).

    CAS  PubMed  Google Scholar 

  20. Folks, T. M. et al. Proc. natn. Acad. Sci. U.S.A. 86, 2365–2368 (1989).

    Article  ADS  CAS  Google Scholar 

  21. Mann, D. L. et al. AIDS Res. hum. Retrovir. 5, 253–255 (1989).

    Article  CAS  PubMed  Google Scholar 

  22. Popovic, M., Sarngadharan, M. G., Read, E. & Gallo, R. Science 224, 497–500 (1984).

    Article  ADS  CAS  PubMed  Google Scholar 

  23. Kosco, M. H., Pflugfelder, E. & Gray, D. J. Immun. 148, 2331–2339 (1992).

    CAS  PubMed  Google Scholar 

  24. Mandel, T. E., Phipps, R. P., Abbot, A & Tew, J. G. Immun. Rev. 53, 29–59 (1980).

    Article  CAS  PubMed  Google Scholar 

  25. Pincus, S., Wehrly, K. & Chesebro, B. J. Immun. 142, 3070–3075 (1989).

    CAS  PubMed  Google Scholar 

  26. Gelderblom, H. R., Hausmann, E. S. H., Ozel, M., Pauli, G. & Koch, M. A. Virology 156, 171–176 (1987).

    Article  CAS  PubMed  Google Scholar 

  27. Posner, M. R., Cavacini, L. A., Emes, C. L., Power, J. & Byrn, R. J. Acqu. Immun. Defic. Syndr. 6, 7–14 (1995).

    Google Scholar 

  28. Posner, M. R. et al. J. Immun. 146, 4325–4332 (1991).

    CAS  PubMed  Google Scholar 

  29. Burton, D. R. et al. Science 266, 1024–1027 (1994).

    Article  ADS  CAS  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Microbiology & Immunology, Virginia Commonwealth University, Box 980678, Richmond, Virginia, 23298-0678, USA

    Sonya L. Heath, J. Grant Tew, John G. Tew & Gregory F. Burton

  2. Department of Anatomy, Division of Immunobiology, Virginia Commonwealth University, Box 980678, Richmond, Virginia, 23298-0678, USA

    Andras K. Szakal

Authors
  1. Sonya L. Heath
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  2. J. Grant Tew
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  3. John G. Tew
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  4. Andras K. Szakal
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  5. Gregory F. Burton
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Heath, S., Tew, J., Tew, J. et al. Follicular dendritic cells and human immunodeficiency virus infectivity. Nature 377, 740–744 (1995). https://doi.org/10.1038/377740a0

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