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Cdc25 cell-cycle phosphatase as a target of c-myc

Nature volume 382, pages 511–517 (1996)Cite this article

Abstract

The product of the proto-oncogene c-myc, in partnership with Max, forms a transcription factor that can promote either oncogenic transformation or apoptosis. The Myc/Max heterodimer binds to elements in the cdc25A gene and activates transcription. Like myc, cdc25A, itself a proto-oncogene, can induce apoptosis in cells depleted of growth factor, and Myc-induced apoptosis also requires cdc25A. These findings indicate that cdc25A is a physiologically relevant transcriptional target of c-myc.

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Authors and Affiliations

  1. Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, 11724, USA

    Konstantin Galaktionov, Xiaocun Chen & David Beach

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  1. Konstantin Galaktionov
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  2. Xiaocun Chen
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  3. David Beach
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Galaktionov, K., Chen, X. & Beach, D. Cdc25 cell-cycle phosphatase as a target of c-myc. Nature 382, 511–517 (1996). https://doi.org/10.1038/382511a0

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