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Transcriptional activation by recruitment

Nature volume 386, pages 569–577 (1997)Cite this article

Abstract

The recruitment model for gene activation stipulates that an activator works by bringing the transcriptional machinery to the DNA. Recent experiments in bacteria and yeast indicate that many genes can be activated by this mechanism. These findings have implications for our understanding of the nature of activating regions and their targets, and for the role of histones in gene regulation.

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  1. Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts, 02138, USA

    Mark Ptashne

  2. Division of Biological Sciences, Lancaster University, Lancaster, LA14YQ, UK

    Alexander Gann

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Ptashne, M., Gann, A. Transcriptional activation by recruitment. Nature 386, 569–577 (1997). https://doi.org/10.1038/386569a0

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