Although some diseases occur when both copies of a gene are mutated, mutation of just one copy of certain tumour-suppressor genes promotes tumorigenesis. Identifying such mutations is arduous, but worth the effort.
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Shannon, K., Le Beau, M. Hay in a haystack. Nature 451, 252–253 (2008). https://doi.org/10.1038/451252a
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DOI: https://doi.org/10.1038/451252a
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