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Structural biology

Actin in a twist

How monomers of the cytoskeletal protein actin join to form the stable polymers crucial to muscle contraction and cellular motility has been a long-standing question. A state-of-the-art approach provides an answer.

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Figure 1: Monomer versus polymer.
Figure 2: The secret of G- to F-actin transition.

References

  1. Dos Remedios, C. G. et al. Physiol. Rev. 83, 433–473 (2003).

    Article  CAS  Google Scholar 

  2. Huxley, H. E. Science 164, 1356–1366 (1969).

    Article  ADS  CAS  Google Scholar 

  3. Geeves, M. A. & Holmes, K. C. Adv. Protein Chem. 71, 161–193 (2005).

    Article  CAS  Google Scholar 

  4. Kabsch, W. et al. Nature 347, 37–44 (1990).

    Article  ADS  CAS  Google Scholar 

  5. Oda, T., Iwasa, M., Aihara, T., Maéda, Y. & Narita, A. Nature 457, 441–445 (2009).| Article |

    Article  ADS  CAS  Google Scholar 

  6. Hanson, J. & Lowy, J. J. Mol. Biol. 6, 46–60 (1963).

    Article  CAS  Google Scholar 

  7. Holmes, K. C. et al. Nature 347, 44–49 (1990).

    Article  ADS  CAS  Google Scholar 

  8. Wang, H. & Stubbs, G. Acta Cryst. A49, 504–513 (1993).

    Article  CAS  Google Scholar 

  9. Otterbein, L. R., Graceffa, P. & Dominguez, R. Science 293, 708–711 (2001).

    Article  CAS  Google Scholar 

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Holmes, K. Actin in a twist. Nature 457, 389–390 (2009). https://doi.org/10.1038/457389a

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