Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Correspondence
  • Published:

ISIS, the intron information system, reveals the high frequency of alternative splicing in the human genome

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

References

  1. Mattick, J.S. Curr. Opin. Genet. Dev. 4, 823–831 (1994).

    Article  CAS  Google Scholar 

  2. Herbert, A. & Rich, A. Nature Genet. 21, 265–269 (1999).

    Article  CAS  Google Scholar 

  3. Fire, A. Trends Genet. 15, 358–363 (1999).

    Article  CAS  Google Scholar 

  4. Chabot, B. Trends Genet. 12, 472–478 (1996).

    Article  CAS  Google Scholar 

  5. Gilbert, W. Nature 271, 501 (1978).

    Article  CAS  Google Scholar 

  6. Breitbart, R., Andreadis, A. & Nadal Ginard, B. Annu. Rev. Biochem. 56, 467–495 (1987).

    Article  CAS  Google Scholar 

  7. Adams, M., Rudner, D. & Rio, D. Curr. Opin. Cell Biol. 8, 331–339 (1996).

    Article  CAS  Google Scholar 

  8. McKeown, M. Annu. Rev. Cell Biol. 8, 133–155 (1992).

    Article  CAS  Google Scholar 

  9. Smith, C.W.J., Patton, J.G. & Nadal-Ginard, B. Annu. Rev. Genet. 23, 527–577 (1989).

    Article  CAS  Google Scholar 

  10. Mironov, A., Fickett, J. & Gelfand, M. Genome Res. 9, 1288–1293 (1999).

    Article  CAS  Google Scholar 

  11. Gautheret, D., Poirot, O., Lopez, F., Audic, S. & Claverie, J.M. Genome Res. 8, 524–530 (1998).

    Article  CAS  Google Scholar 

  12. Hanke, J. et al. Trends Genet. 15, 389–390 (1999).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

We thank B. Huang and D. Kennedy for helpful comments and discussions.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to John S. Mattick.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Croft, L., Schandorff, S., Clark, F. et al. ISIS, the intron information system, reveals the high frequency of alternative splicing in the human genome. Nat Genet 24, 340–341 (2000). https://doi.org/10.1038/74153

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/74153

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing