Abstract
Several genes are required during the early phases of liver specification, proliferation and differentiation1,2,3. Here we report that Prox1 is required for hepatocyte migration. Loss of Prox1 leads to formation of a smaller liver with a reduced population of clustered hepatocytes surrounded by a laminin-rich basal membrane.
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Acknowledgements
We thank M. Murray and S. Kalloway for technical assistance; J. Bonten, U. Ozbek and L. Mann for help with the fluorescence-activated cell sorting and the haematoxylin and eosin staining; and G. Grosveld and J. Cleveland for critically reading this manuscript. This work was partially supported by National Institutes of Health grants GM58462 and EY12162 to G.O., by Cancer Center Support (CORE) grant CA 21765 from the National Cancer Institute, and by the American Lebanese Syrian Associated Charities (ALSAC).
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Sosa-Pineda, B., Wigle, J. & Oliver, G. Hepatocyte migration during liver development requires Prox1. Nat Genet 25, 254–255 (2000). https://doi.org/10.1038/76996
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DOI: https://doi.org/10.1038/76996
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