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An issue of tissues: divining the split personalities of selective estrogen receptor modulators

Nature Medicine volume 6, pages 960–962 (2000)Cite this article

The discovery of coregulators and other recent advances in our understanding of the molecular biology of nuclear receptor action have generated expectations that these exciting basic advances will be translated into new diagnostic and therapeutic approaches for endocrine diseases such as breast cancer.

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Figure 1: Nuclear receptor co-regulators modulate the transcriptional potential of estrogen receptor activated by estradiol, SERMs or growth factors.

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Acknowledgements

N.J. McKenna is a recipient of a Department of Defense Breast Cancer Research Program Postdoctoral Award.

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  1. Department of Molecular and Cellular Biology Baylor College of Medicine, One Baylor Plaza Houston, Texas, 77030

    Neil J. McKenna & Bert W. O'Malley

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  1. Neil J. McKenna
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McKenna, N., O'Malley, B. An issue of tissues: divining the split personalities of selective estrogen receptor modulators. Nat Med 6, 960–962 (2000). https://doi.org/10.1038/79637

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