Moving from a reductionist paradigm to one that views cells as systems will necessitate changes in both the culture and the practice of research.
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Acknowledgements
I thank Markus Covert, Jeremy Edwards, David Letscher and Christophe Schilling for preparing the figures.
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Palsson, B. The challenges of in silico biology. Nat Biotechnol 18, 1147–1150 (2000). https://doi.org/10.1038/81125
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DOI: https://doi.org/10.1038/81125
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