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Targeting 14-3-3zeta in cancer therapy

Cancer Gene Therapy volume 19, pages 153–159 (2012)Cite this article

Abstract

An effective therapeutic target is imperative for cancer treatment, including gene therapy. 14-3-3zeta, a member of the 14-3-3 protein family, acts as a suppressor of apoptosis and has a central role in tumor genesis and progression. Owing to its wide upregulation in human tumors and its involvement in cancer progression and treatment resistance, 14-3-3zeta is currently undergoing extensive investigation as a novel therapeutic target. In this review, we widely investigate the role of 14-3-3zeta in cancer and suggest a potential therapeutic target for new anticancer interventions.

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Acknowledgements

Supported by Scientific and Technological Project of ShaanXi Province (No: 2008K09-09) and National Natural Science Foundation of China (No: 81072083).

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  1. X Yang and W Cao: These authors contributed equally to this work.

Authors and Affiliations

  1. Institute of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi Province, People's Republic of China

    X Yang, W Cao, L Zhang, W Zhang, X Zhang & H Lin

  2. Department of Neurosurgery, Molecular Neurosurgery Laboratory, Brain Tumor Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, M, A, USA

    W Zhang

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Yang, X., Cao, W., Zhang, L. et al. Targeting 14-3-3zeta in cancer therapy. Cancer Gene Ther 19, 153–159 (2012). https://doi.org/10.1038/cgt.2011.85

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