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Specific adipocytokines profiles in patients with hyperactive and/or binge/purge form of anorexia nervosa

European Journal of Clinical Nutrition volume 64, pages 840–844 (2010)Cite this article

Subjects

Abstract

Objective:

The aim of our study was to determine whether eating behaviors and/or physical activity level may explain contradicting results in adipocytokines levels in anorexia nervosa (AN).

Subjects/Methods:

Fasting levels of circulating adipocytokines (adiponectin, resistin and leptin), insulin, glucose, C-reactive protein, cytokines (tumor necrosis factor-α and interleukin (IL)-1β), body composition and resting energy expenditure were measured in 24 women AN patients and 14 women controls. These parameters were compared according to AN subtypes: 15 patients with restrictive (R-AN) form versus 9 patients with binge/purge (BP-AN) form; 15 patients with hyperactive (H-AN) form versus 9 patients with nonhyperactive (NH-AN) form.

Results:

BP-AN patients had significantly higher serum adiponectin levels compared with R-AN patients (P<0.05), and H-AN patients had higher serum leptin and lower serum resistin levels compared with NH-AN patients (P<0.05 for both).

Conclusions:

Our study shows specific adipocytokines profiles depending on the subtype of AN: restrictive versus binge/purge and hyperactive versus Nonhyperactive forms. We suggest that these biological signatures could interfere with the outcome of the disease.

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Acknowledgements

We thank Myriam Coffin for her technical help.

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Author notes

  1. J-P Nogueira and M Maraninchi: These authors contributed equally to this work.

Authors and Affiliations

  1. Department of Nutrition, Metabolic diseases, Endocrinology, University of Aix-Marseille 2, ‘La Timone’ Hospital, Marseille, France

    J-P Nogueira, M Maraninchi, A B-L Corroller, B Vialettes & R Valéro

  2. UMR INSERM 476/INRA 1260/University of Aix-Marseille 2, Faculty of Medicine ‘La Timone’, Marseille, France

    J-P Nogueira, M Maraninchi, A-M Lorec, A Nicolay, H Portugal, R Barone, B Vialettes & R Valéro

  3. Department of Biochemistry, University of Aix-Marseille 2, ‘Sainte Marguerite’ Hospital, Marseille, France

    A-M Lorec, A Nicolay & H Portugal

  4. Biostatistics Research Unit, Laboratory of Education and Research in Medical Information Processing (LERTIM), Faculty of Medicine, EA 3283 Aix-Marseille University, Marseille, France

    J Gaudart

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  1. J-P Nogueira
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Correspondence to R Valéro.

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Nogueira, JP., Maraninchi, M., Lorec, AM. et al. Specific adipocytokines profiles in patients with hyperactive and/or binge/purge form of anorexia nervosa. Eur J Clin Nutr 64, 840–844 (2010). https://doi.org/10.1038/ejcn.2010.66

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  • DOI: https://doi.org/10.1038/ejcn.2010.66

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