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STAT4 but not TRAF1/C5 variants influence the risk of developing rheumatoid arthritis and systemic lupus erythematosus in Colombians

Genes & Immunity volume 9, pages 379–382 (2008)Cite this article

Abstract

The aim of this study was to determine the influence of STAT4 (rs7574865) and TRAF1/C5 (rs10818488 and rs2900180) gene polymorphisms on the risk of developing rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) in a Colombian population. This was a case–control study in which 839 individuals with RA (N=274) and SLE (N=144) and matched healthy controls (N=421) were included. Genotyping was performed by using a polymerase chain reaction system with pre-developed TaqMan allelic discrimination assay. STAT4 rs7574865T allele disclosed a significant influence on the risk of developing SLE (P=0.0005; OR 1.62, 95% CI 1.22–2.16) and RA (P=0.008; OR 1.36; 95% CI 1.08–1.71), whereas no effect on these autoimmune diseases was observed for the TRAF1/C5 polymorphisms examined. Our data strengthen STAT4 rs7574865 polymorphism as a susceptibility factor for RA and SLE and provide further evidence for a common origin of autoimmune diseases.

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Acknowledgements

We thank all the participants in this study. This work was supported by grant SAF2006-00398 from Plan Nacional de I+D+I (Spain), by the Junta de Andalucía, grupo CTS-180 (Spain), the Rosario University (Colombia) and Colciencias, Colombia (grant 1102-04-12905).

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Author notes

  1. J-M Anaya and J Martín: These authors equally contributed to this work.

Authors and Affiliations

  1. Instituto de Biomedicina López-Neyra, Consejo Superior de Investigaciones Científicas, Granada, Spain

    R J Palomino-Morales & J Martín

  2. Cellular Biology and Immunogenetics Unit, Corporación para Investigaciones Biológicas, Universidad del Rosario, Medellin, Colombia

    A Rojas-Villarraga & J-M Anaya

  3. Laboratorio de Inmunología y Biología Molecular, Grupo de Inmunología y Epidemiología Molecular, Facultad de Salud, Universidad Industrial de Santander, Bucaramanga, Colombia

    C I González & G Ramírez

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  1. R J Palomino-Morales
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  2. A Rojas-Villarraga
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  3. C I González
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  4. G Ramírez
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  5. J-M Anaya
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Correspondence to J-M Anaya or J Martín.

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Palomino-Morales, R., Rojas-Villarraga, A., González, C. et al. STAT4 but not TRAF1/C5 variants influence the risk of developing rheumatoid arthritis and systemic lupus erythematosus in Colombians. Genes Immun 9, 379–382 (2008). https://doi.org/10.1038/gene.2008.30

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