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Gfi1 and Gfi1b: key regulators of hematopoiesis

Leukemia volume 24, pages 1834–1843 (2010)Cite this article

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Abstract

Transcription factor Growth factor independence 1 (Gfi1) is required for multilineage blood cell development, from stem and progenitor cells to differentiated lymphoid and myeloid cells. Gfi1 expression is rapidly induced by cytokines that control both the adaptive and innate immune systems. Gfi1 itself represses the expression of genes implicated in cell survival, proliferation and differentiation. Changes in Gfi1 expression and function have not only been implicated in neutropenia, allergy, autoimmunity and hyperinflammatory responses, but also in lymphoma and more recently in the development of leukemia. In this study, we review how Gfi1 and its paralogue Gfi1b control the development of blood cells, discuss how changes in Gfi1 and Gfi1b function contribute to hematological disease and report on the molecular function of these proteins.

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Acknowledgements

We thank Irene D van der Ploeg FRCS (Tr & Orth) for critical reading of the paper.

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  1. L T van der Meer

    Present address: 2Current address: Laboratory of Pediatric Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.,

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  1. Department of Laboratory Medicine, Laboratory of Hematology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

    L T van der Meer, J H Jansen & B A van der Reijden

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  1. L T van der Meer
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van der Meer, L., Jansen, J. & van der Reijden, B. Gfi1 and Gfi1b: key regulators of hematopoiesis. Leukemia 24, 1834–1843 (2010). https://doi.org/10.1038/leu.2010.195

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  • DOI: https://doi.org/10.1038/leu.2010.195

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