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Protein-protein interaction networks and biology—what's the connection?

Nature Biotechnology volume 26, pages 69–72 (2008)Cite this article

Analysis of protein-protein interaction networks is an increasingly popular means to infer biological insight, but is close enough attention being paid to data handling protocols and the degree of bias in the data?

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Figure 1: Visualization of the yeast protein-protein interaction network showing the effect of multiple validation on networks derived from both the LC (Reguly et al.25) and the HC (Batada et al.7) datasets.
Figure 2: Topological analysis of the literature-curated dataset of Reguly et al.25

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Acknowledgements

L.H. was supported by Wellcome Trust VIP funding to S.C.L. J.W.P. is supported by a Biotechnology and Biological Sciences Research Council project grant (BB/C515412/1) to D.L.R. We thank K. Hentges for critical reading of the manuscript.

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  1. Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Rd, Manchester, M13 9PT, UK

    Luke Hakes, John W Pinney, David L Robertson & Simon C Lovell

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Hakes, L., Pinney, J., Robertson, D. et al. Protein-protein interaction networks and biology—what's the connection?. Nat Biotechnol 26, 69–72 (2008). https://doi.org/10.1038/nbt0108-69

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