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Lost in migration

Combinations of cytostatic treatments and chemotherapies currently in clinical practice offer limited hope for patients whose cancers have spread. But increasing understanding of the processes underlying metastasis may one day provide other therapeutic options.

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Figure 1: Steps to metastasis formation.
Figure 2: Cellular pathways associated with bone metastases and associated therapies.
Figure 3: AntiCancer's MetaMouse allows visualization of tumors in whole animals following orthotopic implantation of human pancreatic tumor cells expressing red fluorescent protein.
Figure 4: Potential cellular targets of drugs associated with metastasis.

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Mack, G., Marshall, A. Lost in migration. Nat Biotechnol 28, 214–229 (2010). https://doi.org/10.1038/nbt0310-214

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