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'Magic' scissors for genome surgery

The efficient and permanent alteration of a human gene responsible for SCID provides a proof-of-principle demonstration of the potential of zinc-finger nucleases as human therapeutics.

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Figure 1: ZFN-mediated gene targeting in human cells.

Bob Crimi

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Kandavelou, K., Mani, M., Durai, S. et al. 'Magic' scissors for genome surgery. Nat Biotechnol 23, 686–687 (2005). https://doi.org/10.1038/nbt0605-686

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