Snapshots of computer systems that are stored and shared 'in the cloud' could make computational analyses more reproducible.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Towards reproducible computational drug discovery
Journal of Cheminformatics Open Access 28 January 2020
-
Tools and techniques for computational reproducibility
GigaScience Open Access 11 July 2016
-
The Metagenomics and Metadesign of the Subways and Urban Biomes (MetaSUB) International Consortium inaugural meeting report
Microbiome Open Access 03 June 2016
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Gentleman, R. Stat. Appl. Genet. Mol. Biol. 4, Article 2 (2005).
Gil, Y. et al. Computer 40, 24–32 (2007).
Barker, A. & van Hemert, J. in Parallel Processing and Applied Mathematics (eds. Wyrzykowski, R., Dongarra, J., Karczewski, K. & Wasniewski, J.) 746–753 (Springer; 2008).
Reich, M. et al. Nat. Genet. 38, 500–501 (2006).
Hull, D. et al. Nucleic Acids Res. 34, W729–W732 (2006).
De Roure, D., Goble, C. & Stevens, R. Future Gener. Comput. Syst. 25, 561–567 (2009).
Mesirov, J.P. Science 327, 415–416 (2010).
Ball, C.A., Sherlock, G. & Brazma, A. Nat. Biotechnol. 22, 1179–1183 (2004).
Brooksbank, C. & Quackenbush, J. OMICS 10, 94–99 (2006).
Wiley, H.S. & Michaels, G.S. Nat. Biotechnol. 22, 1037–1038 (2004).
Lynch, C. Nature 455, 28–29 (2008).
Bateman, A. & Wood, M. Bioinformatics 25, 1475 (2009).
Nelson, M.R. Science 324, 1656–1657 (2009).
Osterweil, L.J., Clarke, L.A. & Ellison, A.M. Science 325, 1622 (2009).
Schwab, M., Karrenbach, M. & Claerbout, J. Comput. Sci. Eng. 2, 61–67 (2000).
Wagener, J., Spjuth, O., Willighagen, E.L. & Wikberg, J.E. BMC Bioinformatics 10, 279 (2009).
Merali, Z. & Giles, J. Nature 435, 1010–1011 (2005).
Anonymous. Nature 462, 252 (2009).
Gu, Y. & Grossman, R.L. Eng. Sci. 367, 2429–2445 (2009).
Langille, M.G. & Eisen, J.A. PLoS ONE 5, e10071 (2010).
Stein, L.D. Genome Biol. 11, 207 (2010).
Langmead, B., Schatz, M.C., Lin, J., Pop, M. & Salzberg, S.L. Genome Biol. 10, R134 (2009).
Schatz, M.C. Bioinformatics 25, 1363–1369 (2009).
Giardine, B. et al. Genome Res. 15, 1451–1455 (2005).
Acknowledgements
J.T.D. is supported by the National Library of Medicine Biomedical Informatics Training Grant (T15 LM007033) and A.J.B. is supported by the National Institute for General Medical Sciences (R01 GM079719). We thank D. Singh for valuable discussion regarding cloud-computing technology.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Dudley, J., Butte, A. In silico research in the era of cloud computing. Nat Biotechnol 28, 1181–1185 (2010). https://doi.org/10.1038/nbt1110-1181
Published:
Issue Date:
DOI: https://doi.org/10.1038/nbt1110-1181
This article is cited by
-
Towards reproducible computational drug discovery
Journal of Cheminformatics (2020)
-
Automating NEURON Simulation Deployment in Cloud Resources
Neuroinformatics (2017)
-
Computational Reproducibility in Archaeological Research: Basic Principles and a Case Study of Their Implementation
Journal of Archaeological Method and Theory (2017)
-
Tools and techniques for computational reproducibility
GigaScience (2016)
-
The Metagenomics and Metadesign of the Subways and Urban Biomes (MetaSUB) International Consortium inaugural meeting report
Microbiome (2016)
