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Solving the WAVE function

Nature Cell Biology volume 6, pages 279–281 (2004)Cite this article

SCAR/WAVE proteins are central regulators of cell motility that coordinate actin reorganization through activation of the Arp2/3 complex. Their activity is controlled by a large complex with four other members. A new study contradicts earlier work by suggesting that the entire complex is required for SCAR/WAVE activity at the leading edge.

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Figure 1: Contrasting models for the regulation of SCAR/WAVE activity.

References

  1. Pollard, T. & Borisy, G. Cell 112, 453–465 (2003).

    Article  CAS  PubMed  Google Scholar 

  2. Higgs, H.D. & Pollard, T.P. J. Cell Biol. 150, 1311–1320 (2000).

    Article  CAS  PubMed  Google Scholar 

  3. Machesky, L.M. & Insall, R. Curr. Biol. 8, 1347–1356 (1998).

    Article  CAS  PubMed  Google Scholar 

  4. Eden, S. et al. Nature 418, 790–793 (2002).

    Article  CAS  Google Scholar 

  5. Innocenti, M. et al. Nature Cell. Biol. 6, 319–327 (2004).

    Article  CAS  Google Scholar 

  6. Steffen, A. et al. EMBO J. 23, 749–759 (2004).

    Article  CAS  PubMed  Google Scholar 

  7. Bear, J.E., Rawls, J.F. & Saxe, C.L. J. Cell Biol. 142, 1325–1335 (1998).

    Article  CAS  PubMed  Google Scholar 

  8. Zallen, J.A. et al. D. J. Cell Biol. 156, 689–701 (2002).

    Article  CAS  Google Scholar 

  9. Biyasheva, A. et al. J. Cell Sci. 117, 837–848 (2004).

    Article  CAS  Google Scholar 

  10. Blagg, S.L., Stewart, M., Sambles, C. & Insall, R.H. Curr. Biol. 13, 1480–1487 (2003).

    Article  CAS  Google Scholar 

  11. Bogdan, S. & Klambt, C. Development 130, 4427–4437 (2003).

    Article  CAS  PubMed  Google Scholar 

  12. Kunda, P., Craig, G., Dominguez, V. & Baum, B. Curr. Biol. 13, 1867–1875 (2003).

    Article  CAS  PubMed  Google Scholar 

  13. Rogers, S.L., Wiedemann, U., Stuurman, N. & Vale, R.D. J. Cell Biol. 162, 1079–1088 (2003).

    Article  CAS  PubMed  Google Scholar 

  14. Frank, M.J., Cartwright, H.N. & Smith, L.G. Development 130, 753–762 (2003).

    Article  CAS  Google Scholar 

Download references

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  1. the School of Biosciences, University of Birmingham, Birmingham, B15 2TT, UK

    Simone L. Blagg & Robert H. Insall

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  1. Simone L. Blagg
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  2. Robert H. Insall
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Blagg, S., Insall, R. Solving the WAVE function. Nat Cell Biol 6, 279–281 (2004). https://doi.org/10.1038/ncb0404-279

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