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A mitotic role for the DNA damage-responsive CHK2 kinase

Nature Cell Biology volume 12, pages 424–425 (2010)Cite this article

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Instability in the structure and number of chromosomes is a trait common to cells from most epithelial cancers. A role in chromosome segregation for a pathway previously implicated in the DNA damage response reveals new connections between the tumour suppressive processes that maintain chromosome integrity.

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Figure 1: Contrasting the DNA damage-responsive (left) and mitotic (centre) functions of CHK2 and BRCA1.

References

  1. Holland, A. J. & Cleveland, D. W. Nat. Rev. Mol. Cell Biol. 10, 478–487 (2009).

    Article  CAS  Google Scholar 

  2. Prasanth, S. G., Prasanth, K. V. & Stillman, B. Science 297, 1026–1031 (2002).

    Article  CAS  Google Scholar 

  3. Joukov, V. et al. Cell 127, 539–552 (2006).

    Article  CAS  Google Scholar 

  4. Marmorstein, L. Y. et al. Cell 104, 247–257 (2001).

    Article  CAS  Google Scholar 

  5. Ayoub, N. Rajendra, E., Su, X., Jeyasekharan, A. D., Mahen, R. & Venkitaraman, A. R. Curr. Biol. 19, 1075–85 (2009).

    Article  CAS  Google Scholar 

  6. Stoltz, A. et al. Nat. Cell Biol. 12, 492–499 (2010).

    Article  Google Scholar 

  7. Bartek, J. & Lukas, J. Cancer Cell 3, 421–429 (2003).

    Article  CAS  Google Scholar 

  8. Okada, S. & Ouchi, T. J. Biol. Chem. 278, 2015–2020 (2003).

    Article  CAS  Google Scholar 

  9. Zhang, J. et al. Mol. Cell Biol. 24, 708–718 (2004).

    Article  CAS  Google Scholar 

  10. Andrews, P. D. et al. Dev. Cell 6, 253–268 (2004).

    Article  CAS  Google Scholar 

  11. Knowlton, A. L., Lan, W. & Stukenberg, P. T. Curr. Biol. 16, 1705–1710 (2006).

    Article  CAS  Google Scholar 

  12. Bakhoum, S. F., Thompson, S. L., Manning, A. L. & Compton, D. A. Nat. Cell Biol. 11, 27–35 (2009).

    Article  CAS  Google Scholar 

  13. Bonner, W. M. et al. Nat. Rev. Cancer 8, 957–967 (2008).

    Article  CAS  Google Scholar 

  14. Lopes, M. et al. Nature 412, 557–561 (2001).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Ko Sato and Ashok R. Venkitaraman are in the Department of Oncology and the Medical Research Council Cancer Cell Unit, University of Cambridge, Hutchison/MRC Research Centre, Hills Road, Cambridge, CB2 0XZ arv22@hutchison-mrc.cam.ac.uk,

    Ko Sato & Ashok R. Venkitaraman

  2. Tomohiko Ohta is in the Department of Translational Oncology, St Marianna University Graduate School of Medicine, 2-16-1 Sugao, Miyamae, Kawasaki, 216-8511, Japan.,

    Tomohiko Ohta

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  1. Ko Sato
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  2. Tomohiko Ohta
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  3. Ashok R. Venkitaraman
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Sato, K., Ohta, T. & Venkitaraman, A. A mitotic role for the DNA damage-responsive CHK2 kinase. Nat Cell Biol 12, 424–425 (2010). https://doi.org/10.1038/ncb0510-424

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