Exciting new work identifies phospholipase D2 (PLD2) as an unexpected player upstream of Ras activation in epidermal growth factor (EGF)- and T-cell receptor-regulated signalling pathways. Phosphatidic acid (PA) generated on the plasma membrane by activated PLD2 directly recruits the guanine nucleotide-exchange factor Sos, or after conversion to diacylglycerol (DAG), recruits RasGRP1. These results demand a rewiring of some well-established circuit diagrams.
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Hancock, J. PA promoted to manager. Nat Cell Biol 9, 615–617 (2007). https://doi.org/10.1038/ncb0607-615
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DOI: https://doi.org/10.1038/ncb0607-615
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