Proteins that control the cell cycle would seem to have little to do with cell migration. However, a recent report indicates that Cdc2, a key cyclin-dependent kinase, can also enhance cell migration. Levels of Cdc2 are upregulated in cells that express high levels of the αvβ3 integrin, a protein that has long been implicated in enhanced migration and invasion of tumour cells.
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References
Webb, D.J., Parsons J.T. & Horwitz A.F. Nature Cell Biol. 4, E97–E100 (2002).
Hood, J.D. & Cheresh, D.A. Nature Rev. Cancer 2, 91–100 (2002).
Ridley, A.J. J. Cell Sci. 114, 2713–2722 (2001).
Hsia, D.A. et al. J. Cell Biol. 160, 753–767 (2003).
Bokoch, G.M. Annu. Rev. Biochem. 72, 743–781 (2003).
Worthylake, R.A. & Burridge, K. J. Biol. Chem. 278, 13578–13584 (2003).
Klemke, R.L. et al. J. Cell Biol. 137, 481–492 (1997).
Manes, T. et al. J. Cell Biol. 161, 817–826 (2003).
Pines, J. Nature Cell Biol. 1, E73–E79 (1999).
Neumeister, P. et al. Mol. Biol. Cell 14, 2005–2015 (2003).
Juliano, R.L. Annu. Rev. Pharmacol. Toxicol. 42, 283–323 (2002).
Yamashiro, S. et al. Mol. Biol. Cell 12, 239–250 (2001).
Yamashiro, S. et al. Nature 349, 169–172 (1991).
Helfman D.M. et al. Mol. Biol. Cell 10, 3097–3112 (1999).
Jackman, M. et al. EMBO J. 14, 1646–1654 (1995).
Miller, M.E. & Cross, F.R. J. Cell Sci. 114, 1811–1820 (2001).
Bretscher, M.S. & Aguado-Velasco, C. Curr. Opin. Cell Biol. 10, 537–541 (1998).
Stamnes, M. Curr. Opin. Cell Biol. 14, 428–433 (2002).
Smits, V.A.J. & Medema, R.H. Biochim. Biophys. Acta 1519, 1–12 (2001).
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Juliano, R. Movin' on through with Cdc2. Nat Cell Biol 5, 589–590 (2003). https://doi.org/10.1038/ncb0703-589
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DOI: https://doi.org/10.1038/ncb0703-589
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