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Centriole biogenesis: a tale of two pathways

Nature Cell Biology volume 9, pages 736–738 (2007)Cite this article

Two recent studies in Drosophila demonstrate that overexpression of proteins required for centriole duplication can not only induce centriole over-duplication in cells containing centrioles, but can also drive de novo centriole assembly in unfertilized eggs that initially lack centrioles. These studies offer a new perspective on the mechanisms that control centriole duplication.

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Figure 1: Effects of Sak/Plk4 overexpression in different cell types.
Figure 2: Mechanisms of centriole reduplication when Sak/Plk4 or Sas6 are overexpressed.

References

  1. Nigg, E. A. International Journal of Cancer 119, 2717–2723 (2006).

    Google Scholar 

  2. Rodrigues-Martins, A., Riparbelli, M., Callaini, G., Glover, D. M. & Bettencourt-Dias, M. Science 316, 1046–1050 (2007).

    Article  CAS  Google Scholar 

  3. Peel, N., Stevens, N. R., Basto, R. & Raff, J. W. Curr. Biol. 17, 834–843 (2007).

    Article  CAS  Google Scholar 

  4. Bettencourt-Dias, M. et al. Curr. Biol. 15, 2199–2207 (2005).

    Article  CAS  Google Scholar 

  5. Habedank, R., Stierhof, Y. D., Wilkinson, C. J. & Nigg, E. A. Nature Cell Biol. 7, 1140–1146 (2005).

    Article  Google Scholar 

  6. Delattre, M., Canard, C. & Gonczy, P. Curr. Biol. 16, 1844–1849 (2006).

    Article  CAS  Google Scholar 

  7. Pelletier, L., O'Toole, E., Schwager, A., Hyman, A. A. & Muller-Reichert,T. Nature 444, 619–623 (2006).

    Article  CAS  Google Scholar 

  8. Tsou, M. F. & Stearns, T. Nature 442, 947–951 (2006).

    Article  CAS  Google Scholar 

  9. Szollosi, D., Calarco, P. & Donahue, R. P. J. Cell Sci. 11, 521–541 (1972).

    CAS  PubMed  Google Scholar 

  10. Uetake, Y. et al. J. Cell Biol. 176, 173–182 (2007).

    Article  CAS  Google Scholar 

  11. La Terra, S. et al. J. Cell Biol. 168, 713–720 (2005).

    Article  CAS  Google Scholar 

  12. Duensing, A. et al. Oncogene doi:10.1038/sj.onc.1210456 (2007).

  13. Nigg, E. A. Trends Cell Biol. 17, 215–221 (2007).

    Article  CAS  Google Scholar 

  14. Dammermann, A. et al. Dev. Cell 7, 815–829 (2004).

    Article  CAS  Google Scholar 

  15. Young, A., Dictenberg, J. B., Purohit, A., Tuft, R. & Doxsey, S. J. Mol. Biol. Cell 11, 2047–2056 (2000).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Jadranka Loncarek and Alexey Khodjakov are in the Division of Molecular Medicine, Wadsworth Center, Albany NY 12201–0509, USA. khodj@wadsworth.org,

    Jadranka Loncarek & Alexey Khodjakov

  2. Greenfield Sluder is in the Department of Cell Biology, University of Massachusetts Medical School, Worcester MA 01605, USA. Greenfield.Sluder@umassmed.edu,

    Greenfield Sluder

Authors
  1. Jadranka Loncarek
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  2. Greenfield Sluder
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  3. Alexey Khodjakov
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Loncarek, J., Sluder, G. & Khodjakov, A. Centriole biogenesis: a tale of two pathways. Nat Cell Biol 9, 736–738 (2007). https://doi.org/10.1038/ncb0707-736

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