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From chromatin to cancer: a new histone lysine methyltransferase enters the mix

Nature Cell Biology volume 6, pages 685–687 (2004)Cite this article

Disruption of post-translational modifications of histone proteins perturbs the proper pattern of gene expression and has the potential to result in diseases, such as cancer. A study implicating a new histone lysine methyltransferase in tumorigenesis further corroborates the emerging link between cancer and epigenetics.

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Figure 1: Potential model for SMYD3-mediated histone H3-K4 methylation.
Figure 2: Model for cellular transformation by high levels of SMYD3.

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Authors and Affiliations

  1. Department of Biochemistry,

    Robert J. Sims 3rd & Danny Reinberg

  2. Department of Biochemistry, Howard Hughes Medical Institute, Robert Wood Johnson Medical School, Piscataway, 08854, NJ, USA

    Robert J. Sims 3rd & Danny Reinberg

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  1. Robert J. Sims 3rd
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  2. Danny Reinberg
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Sims, R., Reinberg, D. From chromatin to cancer: a new histone lysine methyltransferase enters the mix. Nat Cell Biol 6, 685–687 (2004). https://doi.org/10.1038/ncb0804-685

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