The RhoGTPases Rac and Rho are important for orchestrating cytoskeletal dynamics during cell migration and crosstalk to antagonize each others' activities. The discovery of a Rac GTPase activating protein (GAP) that is regulated by Rho and Rho kinase (ROCK) provides a new basis for this crosstalk.
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Burridge, K., Doughman, R. Front and back by Rho and Rac. Nat Cell Biol 8, 781–782 (2006). https://doi.org/10.1038/ncb0806-781
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DOI: https://doi.org/10.1038/ncb0806-781
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