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terra is a left–right asymmetry gene required for left–right synchronization of the segmentation clock

An Erratum to this article was published on 23 September 2005

Abstract

To establish the vertebrate body plan, it is fundamental to create left–right asymmetry in the lateral-plate mesoderm to correctly position the organs. However, it is also crucial to maintain symmetry between the left and the right sides of the presomitic mesoderm, ensuring the allocation of symmetrical body structures, such as the axial skeleton and skeletal muscles. Here, we show that terra is an early left-sided expressed gene that links left–right patterning with bilateral synchronization of the segmentation clock.

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Figure 1: Terra is required for L–R coordination of the segmentation clock.
Figure 2: Terra is required for L–R patterning.

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References

  1. Meng, A. et al. Development 126, 1259–1268 (1999).

    CAS  PubMed  Google Scholar 

  2. Brunner, B. et al. Genomics 77, 8–17 (2001).

    Article  CAS  Google Scholar 

  3. Dubrulle, J. & Pourquié, O. Development 131, 5783–5793 (2004).

    Article  CAS  Google Scholar 

  4. Jiang, Y.J. et al. Nature 408, 475–479 (2000).

    Article  CAS  Google Scholar 

  5. Holley, S.A. et al. Genes Dev. 14, 1678–1690 (2000).

    CAS  PubMed  PubMed Central  Google Scholar 

  6. Oates, A.C. & Ho, R.K. Development 129, 2929–2946 (2002).

    CAS  PubMed  Google Scholar 

  7. Cooke, J. & Zeeman, E.C. J. Theor. Biol. 58, 455–476 (1976).

    Article  CAS  Google Scholar 

  8. Vermot, J. et al. Science 308, 563–566 (2005).

    Article  CAS  Google Scholar 

  9. Kawakami, Y. et al. Nature 435, 165–171 (2005).

    Article  CAS  Google Scholar 

  10. Vermot, J. & Pourquié, O. Nature 435, 215–220 (2005).

    Article  CAS  Google Scholar 

  11. Hamada, H. et al. Nature Rev. Genet. 3, 103–113 (2002).

    Article  CAS  Google Scholar 

  12. Long, S. et al. Development 130, 2303–2316 (2003).

    Article  CAS  Google Scholar 

  13. Hashimoto, H. et al. Development 131, 1741–1753 (2004).

    Article  CAS  Google Scholar 

  14. Amack, J.D. & Yost, J. Curr. Biol. 14, 685–690 (2004).

    Article  CAS  Google Scholar 

  15. Hamburger, V. & Hamilton, H.L. J. Morphol. 88, 49–92 (1951).

    Article  CAS  Google Scholar 

  16. Essner, J.J. et al. Development 127, 1081–1093 (2000).

    CAS  PubMed  Google Scholar 

  17. Raya, A. et al. Nature 427, 121–128 (2004).

    Article  CAS  Google Scholar 

  18. Kimmel, C.B. et al. Dev. Dyn. 203, 253–310 (1995).

    Article  CAS  Google Scholar 

  19. Thisse, C. & Thisse, B. in Zebrafish Science Monitor 5, 8–9 (1998).

    Google Scholar 

  20. Henrique, D. et al. Nature 375, 787–790 (1995)

    Article  CAS  Google Scholar 

Download references

Acknowledgements

We thank S. Wilson and D. Stemple for the zebrafish embryos, M. Tada and C.-P. Heisenberg for reagents, I. Campos for technical support with MO injections, A. Gaspar for histological work, C. Domingues for the SDS–PAGE gels and I. Marques for sequence analysis. We are grateful to S. Thorsteinsdóttir, S. Simões, W. Wood, S. Rodrigues, R. Andrade, A. Jacinto and A. Coutinho for comments on the manuscript. This work was supported by a grant from Fundação para a Ciência e a Tecnologia (FCT) (POCTI/45914/BCI/2002). L.S. was supported by a FCT fellowship (SFRH/BPD/6755/2001). R.L. was supported by Fundação Calouste Gulbenkian (FCG)/Instituto do Emprego e Formação Profissional (IEFP). The authors are members of the FP6 European Network of Excellence 'Cells into Organs'.

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Correspondence to Leonor Saúde.

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Supplementary figure S1, S2, S3, S4 and Supplementary methods (PDF 459 kb)

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Saúde, L., Lourenço, R., Gonçalves, A. et al. terra is a left–right asymmetry gene required for left–right synchronization of the segmentation clock. Nat Cell Biol 7, 918–920 (2005). https://doi.org/10.1038/ncb1294

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