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Physicochemical modelling of cell signalling pathways

Nature Cell Biology volume 8, pages 1195–1203 (2006)Cite this article

Abstract

Physicochemical modelling of signal transduction links fundamental chemical and physical principles, prior knowledge about regulatory pathways, and experimental data of various types to create powerful tools for formalizing and extending traditional molecular and cellular biology.

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Figure 1: The modify–measure–mine–model paradigm in systems biology.
Figure 2: Physicochemical modelling involves a trade off between increasing scope and falling detail.
Figure 3: Steps in physicochemical modelling.
Figure 4: Sensitivity analysis and parameter estimation are context specific.

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Acknowledgements

We thank G. Danuser, J. Gunawardena, B. Schoeberl and W. Fontana for critical reading of this manuscript. This work was funded by a National Institutes of Health (NIH) grant P50-GM68762 and a Deparment of Energy (DOE) Computational Science Graduate Fellowship to B.B.A. (DE-FG02-97ER25308).

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Authors and Affiliations

  1. Department Biological Engineering, Center for Cell Decision Processes, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, 02139, MA, USA

    Bree B. Aldridge, John M. Burke, Douglas A. Lauffenburger & Peter K. Sorger

  2. Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, 02115, MA, USA

    Bree B. Aldridge & Peter K. Sorger

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Aldridge, B., Burke, J., Lauffenburger, D. et al. Physicochemical modelling of cell signalling pathways. Nat Cell Biol 8, 1195–1203 (2006). https://doi.org/10.1038/ncb1497

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