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Sensing RNA virus infections

RIG-I is an RNA helicase that senses viral infections and triggers innate and adaptive immune mechanisms. Recent studies have identified RNAs bearing 5′-triphosphates as ligands of RIG-I and have suggested a mechanism for how RIG-I distinguishes viral RNA from host RNA.

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Figure 1: RIG-I recognizes RNAs with 5′-triphosphates.

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Basler, C., García-Sastre, A. Sensing RNA virus infections. Nat Chem Biol 3, 20–21 (2007). https://doi.org/10.1038/nchembio0107-20

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