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Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population

Abstract

Prostate cancer is one of the most common malignancies in males throughout the world1, and its incidence is increasing in Asian countries. We carried out a genome-wide association study and replication study using 4,584 Japanese men with prostate cancer and 8,801 control subjects. From the thirty-one associated SNPs reported in previous genome-wide association studies in European populations, we confirmed the association of nine SNPs at P < 1.0 × 10−7 and ten SNPs at P < 0.05 in the Japanese population. The remaining 12 SNPs showed no association (P > 0.05). In addition, we report here five new loci for prostate cancer susceptibility, at 5p15 (λ-corrected probability PGC = 3.9 × 10−18), GPRC6A/RFX6 (PGC = 1.6 × 10−12), 13q22 (PGC = 2.8 × 10−9), C2orf43 (PGC = 7.5 × 10−8) and FOXP4 (PGC = 7.6 × 10−8). These findings advance our understanding of the genetic basis of prostate carcinogenesis and also highlight the genetic heterogeneity of prostate cancer susceptibility among different ethnic populations.

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Figure 1: Case-control association results and LD maps of the five new prostate cancer susceptibility loci.

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Acknowledgements

We thank K. Ashikawa, H. Amitani and other staff from the Laboratory for Genotyping Development, Center for Genomic Medicine, RIKEN for their contribution to SNP genotyping, K. Boroevich for comments on the manuscript, and members of the BioBank Japan project and the Rotary Club of Osaka-Midosuji District 2660 Rotary International in Japan for supporting our study. This work was conducted as a part of the BioBank Japan Project, which was supported by the Ministry of Education, Culture, Sports, Sciences and Technology of the Japanese government.

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Authors

Contributions

Y.N. conceived the study; Y.N., R.T., S.A., M.K. and H.N. designed the study; R.T., S.A., N.H. and M.K. performed genotyping; R.T., S.A., M.K., Y.N. and H.N. wrote the manuscript; A.T., T.K., T.T. and N.K. performed data analysis at the genome-wide phase; Y.N., H.N. and M.K. managed DNA samples; R.T. and H.N. summarized the results; Y.N., O.O., T.F. and J.I. obtained funding for the study.

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Correspondence to Hidewaki Nakagawa.

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The authors declare no competing financial interests.

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Supplementary Figures 1 and 2 and Supplementary Tables 1–6 (PDF 681 kb)

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Takata, R., Akamatsu, S., Kubo, M. et al. Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population. Nat Genet 42, 751–754 (2010). https://doi.org/10.1038/ng.635

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