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Open-access database of candidate associations from a genome-wide SNP scan of the Framingham Heart Study

Nature Genetics volume 39, pages 135–136 (2007)Cite this article

To the Editor:

Knowledge from the HapMap and the development of massively parallel genotyping technologies has enabled high-density genotyping of large populations at low cost using a common set of SNPs. We have identified 251 candidate associations with quantitative traits from an analysis of the Framingham Heart Study Offspring Cohort, which we genotyped at a density of 116,000 SNPs per individual using the Affymetrix 100K Human Mapping arrays. These and similar arrays are also being used in studies of other population samples, making it possible to validate associations in silico by comparison of results from the independent analyses. To facilitate this exchange of information, we have created a website to rapidly disseminate the large number of candidate associations uncovered in our study. The associations and additional gene information are available through an open-access website named GMED (for 'genomic medicine database') accessible at http://gmed.bu.edu.

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Author notes

  1. Alan Herbert and Marc E Lenburg: These authors contributed equally to this work.

Authors and Affiliations

  1. Department of Genetics and Genomics, Boston University School of Medicine, Boston, 02118, Massachusetts, USA

    Alan Herbert, Marc E Lenburg, Norman P Gerry, Karen Schlauch & Michael F Christman

  2. GeneHome, Inc., Brookline, 02445, Massachusetts, USA

    David Ulrich

Authors
  1. Alan Herbert
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  2. Marc E Lenburg
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  3. David Ulrich
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  4. Norman P Gerry
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  5. Karen Schlauch
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  6. Michael F Christman
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The authors declare no competing financial interests.

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Herbert, A., Lenburg, M., Ulrich, D. et al. Open-access database of candidate associations from a genome-wide SNP scan of the Framingham Heart Study. Nat Genet 39, 135–136 (2007). https://doi.org/10.1038/ng0207-135

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