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Deregulation of both imprinted and expressed alleles of the insulin–like growth factor 2 gene during β–cell tumorigenesis

Nature Genetics volume 10, pages 196–201 (1995)Cite this article

Abstract

In a mouse model of multistage carcinogenesis elicited by the SV40 large T–antigen (Tag) oncogene in pancreatic β cells, the gene for insulin–like growth factor IGF2 is focally up–regulated and functionally implicated in tumour development. The IGF2 gene is differentially regulated in normal tissues: the paternal allele is transiently expressed during embryogenesis, whereas the maternal allele is genomically imprinted and inactive. Crossbred mice carrying the Tag oncogene and a disruption of either the paternal or maternal allele of IGF2 reveal that both alleles are co–activated early during tumour development, and that each contributes to malignant hyperproliferation and consequent tumour volume.

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Author notes

  1. Gerhard Christofori

    Present address: Research Institute of Molecular Pathology, Dr. Bohr-Gasse 7, 1030, Vienna, Austria

Authors and Affiliations

  1. Department of Biochemistry & Biophysics, Hormone Research Institute, University of California, San Francisco, California, 94143-0534, USA

    Gerhard Christofori, Paul Naik & Douglas Hanahan

Authors
  1. Gerhard Christofori
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  2. Paul Naik
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  3. Douglas Hanahan
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Christofori, G., Naik, P. & Hanahan, D. Deregulation of both imprinted and expressed alleles of the insulin–like growth factor 2 gene during β–cell tumorigenesis. Nat Genet 10, 196–201 (1995). https://doi.org/10.1038/ng0695-196

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  • DOI: https://doi.org/10.1038/ng0695-196

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