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Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14

Nature Genetics volume 2, pages 330–334 (1992)Cite this article

Abstract

Familial Alzheimer's disease (FAD) has been shown to be genetically heterogeneous, with a very small proportion of early onset pedigrees being associated with mutations in the amyloid precursor protein (APP) gene on chromosome 21, and some late onset pedigrees showing associations with markers on chromosome 19. We now provide evidence for a major early onset FAD locus on the long arm of chromosome 14 near the markers D14S43 and D14S53 (multipoint lod score ẑ = 23.4) and suggest that the inheritance of FAD may be more complex than had initially been suspected.

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Author information

Authors and Affiliations

  1. Division of Neurology, Depts of Medicine and Physiology, Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada, M5S 1A8

    P. St George-Hyslop, E. Rogaev, M. Mortilla, G. Vaula, E. Rogaeva, Y. Liang, N. Alexandrova, W. Lukiw & D. Crapper McLachlan

  2. Molecular Neurogenetics Laboratory, Massachusetts General Hospital, CNY-6, Charlestown, Massachusetts, 02129, USA

    J. Haines, K. Schlumpf, R. Tanzi & J. Gusella

  3. National Research Center of Mental Health, Laboratory of Molecular Brain Genetics, Academy of Medical Sciences, Moscow, Russia, Zagorodnoe sh. 2/2, 113152

    E. Rogaev

  4. Dept of Neurology, University of Florence, viale Morgagni 85, Firenze, Italy

    M. Mortilla, S. Sorbi & L. Amaducci

  5. Dept of Neurology, University of Turin, via Cherasco 15, 10126, Torino, Italy

    G. Vaula, I. Rainero, L. Pinessi & L. Bergamini

  6. Bryan Alzheimer's Disease Research Center, Duke University Medical Center, Durham, North Carolina, 27710, USA

    M. Pericak-Vance & A. Roses

  7. Laboratoire de Neurohistologie, Ecole Pratique des Hautes Etudes, La Salpéetrière, 75651, Paris CEDEK, 13, France

    J-F Foncin

  8. Servizio di Neurologia, USSL-17, CNR, via Trento, 88046, Lamezia Terme, Italy

    M. Montesi & A. Bruni

  9. Dept of Neurology, University of Massachusetts Medical Center, 55 Lake Street, Worcester, Massachusetts, 01655, USA

    D. Pollen

  10. Sandoz Research Institute, Sandoz Pharmaceuticals Corporation, 59 Route 10, East Hanover, New Jersey, 07936, USA

    R. Polinsky

  11. Clinical Neuropharmacology Section, NINDS, 9000 Rockville Pike, Bethesda, Maryland, 20892, USA

    L. Nee

  12. Neurogenetics Section, Clarke Institute of Psychiatry, Dept. of Psychiatry, University of Toronto, Toronto, Ontario, Canada, M5T 1R8

    J. Kennedy

  13. Dept. of Neurosciences, University of Milano School of Medicine, 20127, Milano, Italy

    F. Macciardi

  14. Dept of Neurology, Tohoku University School of Medicine, Sendai, Japan

    T. Tsuda

  15. Neurogenetics Laboratory, Boston University School of Medicine, Concord Ave, Boston, Massachusetts, USA

    L. Farrer

  16. Dept of Genetics, Istitituo Mexicano del Seguro Social, Guadalajara, Jalisco, Mexico

    J-M Cantu

  17. Wein Center, Mt Sinai Medical Center, Miami Beach, Florida, 33140, USA

    R. Duara

Authors
  1. P. St George-Hyslop
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  2. J. Haines
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  3. E. Rogaev
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  4. M. Mortilla
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  5. G. Vaula
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  6. M. Pericak-Vance
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  7. J-F Foncin
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  8. M. Montesi
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  9. A. Bruni
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  10. S. Sorbi
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  11. I. Rainero
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  13. D. Pollen
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  14. R. Polinsky
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  15. L. Nee
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  16. J. Kennedy
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  17. F. Macciardi
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  18. E. Rogaeva
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  19. Y. Liang
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  20. N. Alexandrova
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  21. W. Lukiw
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  22. K. Schlumpf
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  23. R. Tanzi
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  24. T. Tsuda
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  25. L. Farrer
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  26. J-M Cantu
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  27. R. Duara
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  28. L. Amaducci
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  29. L. Bergamini
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  30. J. Gusella
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  31. A. Roses
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  32. D. Crapper McLachlan
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St George-Hyslop, P., Haines, J., Rogaev, E. et al. Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14. Nat Genet 2, 330–334 (1992). https://doi.org/10.1038/ng1292-330

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  • DOI: https://doi.org/10.1038/ng1292-330

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