Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Brief Communication
  • Published:

Seborrhea-like dermatitis with psoriasiform elements caused by a mutation in ZNF750, encoding a putative C2H2 zinc finger protein

Abstract

We describe an Israeli Jewish Moroccan family presenting with autosomal dominant seborrhea-like dermatosis with psoriasiform elements, including enhanced keratinocyte proliferation, parakeratosis, follicular plugging, Pityrosporum ovale overgrowth and dermal CD4 lymphocyte infiltrate. We mapped the disease gene to a 0.5-cM region overlapping the PSORS2 locus (17q25) and identified a frameshift mutation in ZNF750, which encodes a putative C2H2 zinc finger protein. ZNF750 is normally expressed in keratinocytes but not in fibroblasts and is barely detectable in CD4 lymphocytes.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Disease phenotype.
Figure 2: Genetic mapping, mutation identification and expression analysis.

Similar content being viewed by others

Accession codes

Accessions

GenBank/EMBL/DDBJ

References

  1. Plewig, G. & Jansen, T. in Fitzpatrick's Dermatology in General Medicine 5th edn., Vol. 1 (Freedberg, I.M. et al., eds.) 1482–1489 (New York, McGraw-Hill, 1999).

    Google Scholar 

  2. Gupta, A.K., Madzia, S.E. & Batra, R. Dermatology 208, 89–93 (2004).

    Google Scholar 

  3. BraunFalco, O. et al. Dermatology. Berlin, Springer, 1991.

    Book  Google Scholar 

  4. Faergemann, J. et al. Br. J. Dermatol. 144, 549–556 (2001).

    Article  CAS  Google Scholar 

  5. Gupta, A.K. et al. J. Am. Acad. Dermatol. 51, 785–798 (2004).

    Article  Google Scholar 

  6. Bowcock, A.M. & Krueger, J.G. Nat. Rev. Immunol. 5, 699–711 (2005).

    Article  CAS  Google Scholar 

  7. Fishelson, M. & Geiger, D. Bioinformatics 18 (Suppl.), S189–S198 (2002).

    Article  Google Scholar 

  8. Pabo, C.O., Peisach, E. & Grant, R.A. Annu. Rev. Biochem. 70, 313–340 (2001).

    Article  CAS  Google Scholar 

  9. Watanabe, S. et al. J. Invest. Dermatol. 116, 769–773 (2001).

    Article  CAS  Google Scholar 

  10. Tomfohrde, J. et al. Science 264, 1141–1145 (1994).

    Article  CAS  Google Scholar 

  11. Helms, C. et al. Nat. Genet. 35, 349–356 (2003).

    Article  CAS  Google Scholar 

  12. Capon, F. et al. J. Med. Genet. 41, 459–460 (2004).

    Article  CAS  Google Scholar 

  13. Hwu, W.L. et al. J. Med. Genet. 42, 152–158 (2005).

    Article  CAS  Google Scholar 

  14. Stuart, P. et al. J. Med. Genet. 43, 12–17 (2006).

    Article  CAS  Google Scholar 

  15. Cohen-Sfady, M. et al. J. Immunol. 175, 3594–3602 (2005).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

We deeply thank the Morris Kahn Foundation for Humanitarian Support for making this research possible.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Ohad S Birk.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Supplementary information

Supplementary Fig. 1

Disease phenotype (continued). (PDF 130 kb)

Supplementary Fig. 2

Mutation analysis of ZNF750 exon 2. (PDF 110 kb)

Supplementary Table 1

Variation in severity of cutaneous manifestations was observed among 10 affected family members studied in detail. (PDF 49 kb)

Supplementary Table 2

PCR primers. (PDF 59 kb)

Supplementary Methods (PDF 110 kb)

Rights and permissions

Reprints and permissions

About this article

Cite this article

Birnbaum, R., Zvulunov, A., Hallel-Halevy, D. et al. Seborrhea-like dermatitis with psoriasiform elements caused by a mutation in ZNF750, encoding a putative C2H2 zinc finger protein. Nat Genet 38, 749–751 (2006). https://doi.org/10.1038/ng1813

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ng1813

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing